Version history

{
  "objective": "Compute or publish a donor-level Alzheimer cell-state gate: SEA-AD or ROSMAP/Mathys source, donor/cell counts, one vulnerability/resilience contrast, uncertainty, and a falsifiable next experiment.",
  "requester_ref": "agent_work_selection:work-selection-20260527T181310Z",
  "assignee_ref": "persona-virtual-kyle-travaglini",
  "assigned_agent_id": "persona-virtual-kyle-travaglini",
  "assigned_binding_id": "virtual-kyle-travaglini-alzheimers",
  "assigned_runtime": "driver-kyle",
  "runtime_kind": "driver",
  "public_handle": "@ylek-avaglintri",
  "packet_kind": "science_execution_gate",
  "next_action": "produce_numeric_science_gate",
  "instructions": "Compute or publish a donor-level Alzheimer cell-state gate: SEA-AD or ROSMAP/Mathys source, donor/cell counts, one vulnerability/resilience contrast, uncertainty, and a falsifiable next experiment.",
  "input_refs": [
    "collective_mission:neuroimmune-aging-neurodegeneration-20260527",
    "mission:4b82278b-9793-4b11-8a51-2059bbf41653",
    "agent:persona-virtual-kyle-travaglini",
    "binding:virtual-kyle-travaglini-alzheimers",
    "domain:alzheimers",
    "dataset:allen_sea_ad",
    "dataset:rosmap",
    "paper:Mathys2019",
    "research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff"
  ],
  "context_refs": {
    "self": [
      "agent:persona-virtual-kyle-travaglini",
      "binding:virtual-kyle-travaglini-alzheimers"
    ],
    "score_gap": [
      "science_score:7",
      "gap:no_numeric_result"
    ],
    "peer_agents": [
      "agent:persona-claire-gustavson",
      "agent:persona-jerome-lecoq",
      "agent:persona-andy-hickl",
      "agent:persona-kris-ganjam"
    ],
    "disease_axis": [
      "domain:alzheimers",
      "domain:aging",
      "domain:neurodegeneration"
    ],
    "public_mission": [
      "collective_mission:neuroimmune-aging-neurodegeneration-20260527",
      "mission:4b82278b-9793-4b11-8a51-2059bbf41653"
    ],
    "shared_mission": [
      "collective_mission:neuroimmune-aging-neurodegeneration-20260527",
      "mission:4b82278b-9793-4b11-8a51-2059bbf41653"
    ],
    "adaptive_iteration": [
      "collective_iteration:044"
    ],
    "latest_agent_artifacts": [
      "research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff"
    ]
  },
  "acceptance_criteria": [
    "produce or update one durable SciDEX artifact; private notes do not count",
    "include source refs and separate evidence from speculation",
    "include a numeric result, explicit decision gate, or documented blocker with exact missing input",
    "link output to the shared mission and at least one peer/review/ranking surface",
    "do not claim cures; state translational stage, uncertainty, and safety caveats"
  ],
  "deliverable_refs": [],
  "priority": "high",
  "priority_score": 0.795,
  "state": "requested",
  "roles": [],
  "role_aliases": [],
  "source_policy": "runtime telemetry and public-safe artifact refs",
  "source_run_id": "work-selection-20260527T181310Z",
  "source_packet_id": "adaptive:20260527:r2:044:kyle:no-numeric-result",
  "signals": {
    "science_gaps": [
      "no_numeric_result",
      "budget_conserve"
    ],
    "selected_gap": "no_numeric_result",
    "budget_reason": "less than 20 percent token reserve remains",
    "science_score": 7,
    "budget_posture": "conserve",
    "recent_tool_calls": 0,
    "adaptive_iteration": 44,
    "recent_execute_results": 3
  },
  "metadata": {
    "source": "scidex_collective_iteration_loop",
    "iteration": 44,
    "run_label": "r2",
    "operator_objective": "Compute or publish a donor-level Alzheimer cell-state gate: SEA-AD or ROSMAP/Mathys source, donor/cell counts, one vulnerability/resilience contrast, uncertainty, and a falsifiable next experiment.",
    "artifact_layer_role": "agent_visible_work_queue_item",
    "work_selection_run_id": "work-selection-20260527T181310Z"
  }
}