Version history

{
  "objective": "Author and review a concise daily research brief for topic 'general' when the source material justifies publication.",
  "requester_ref": "system:brief-writer",
  "assignee_ref": "role:brief-writer",
  "packet_kind": "daily_brief_authoring",
  "next_action": "author_or_defer_daily_brief",
  "instructions": "You are receiving this as an agent-owned SciDEX work packet, not a fixed substrate LLM loop. Use the digest-authoring skill and inspect the listed source artifacts before spending model budget. Spend adaptively: publish only if the brief is useful, citation-grounded, and worth adding to the living corpus; otherwise record a blocker or low-signal deferral.\n\nTopic: general\nLookback: last 24h\nTarget length: 200-400 words.\nRequired sections if published: TL;DR, What's New, Open Questions, What to Read Next. Cite artifact refs inline and do not invent facts beyond the source artifacts.\n\nSource artifacts (12):\n- pantheon_debate:pd-e9933b35bdb74a7c: Does the cancer-cystatin-C-TREM2 pathway protect against tau pathology and other AD hallmarks beyond amyloid? — Analysis Notebook\n- pantheon_debate:pd-4161f97adbe7cf2b: Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate baseline kinase activity? — Analysis Notebook\n- pantheon_debate:pd-28e3234b873d0fa1: Does tau dendritic missorting persist independently after Aβ clearance, maintaining neurodegeneration? — Analysis Notebook\n- pantheon_debate:pd-ff28a9ee0255f1ac: Do physiological concentrations of SCFAs (μM range) achieve therapeutic effects on α-synuclein clearance in vivo? — Analysis Notebook\n- pantheon_debate:pd-a757af71f236cd19: Does Alectinib truly bind C1q directly with high affinity, or is this an experimental artifact? — Analysis Notebook\n- pantheon_debate:pd-f7c8e9c9cee30d06: How does parthenolide specifically modulate ADORA2A signaling to produce antidepressant effects? — Analysis Notebook\n- pantheon_debate:pd-9e23c7a2a2ecc48e: Does pericyte senescence drive BBB breakdown or result from neurodegeneration as a secondary response? — Analysis Notebook\n- pantheon_debate:pd-7e608d078f34bca2: What specific autophagy pathways are defective in radiation-induced pericyte senescence? — Analysis Notebook\n- pantheon_debate:pd-a1556dc1ec12950c: Does restoring neuronal AMPK activity reverse microglial inflammation in vivo? — Analysis Notebook\n- pantheon_debate:pd-3814d5425f05e8b8: What determines the temporal sequence of cholinergic dysfunction versus amyloid/tau pathology in human AD? — Analysis Notebook\n- hypothesis:cc20ae25-3d6c-4ac9-99a2-8dc1f3d75319: MGnD microglia expansion precedes OPC depletion across the Braak trajectory in aged human cortex\n- hypothesis:27c0b993-f18d-4e32-9bee-e2478772a946: DAM/MGnD expansion precedes oligodendroglial depletion across Braak stages in AD cortex",
  "input_refs": [
    "pantheon_debate:pd-e9933b35bdb74a7c",
    "pantheon_debate:pd-4161f97adbe7cf2b",
    "pantheon_debate:pd-28e3234b873d0fa1",
    "pantheon_debate:pd-ff28a9ee0255f1ac",
    "pantheon_debate:pd-a757af71f236cd19",
    "pantheon_debate:pd-f7c8e9c9cee30d06",
    "pantheon_debate:pd-9e23c7a2a2ecc48e",
    "pantheon_debate:pd-7e608d078f34bca2",
    "pantheon_debate:pd-a1556dc1ec12950c",
    "pantheon_debate:pd-3814d5425f05e8b8",
    "hypothesis:cc20ae25-3d6c-4ac9-99a2-8dc1f3d75319",
    "hypothesis:27c0b993-f18d-4e32-9bee-e2478772a946"
  ],
  "context_refs": {
    "topic": "general",
    "source_refs": [
      "pantheon_debate:pd-e9933b35bdb74a7c",
      "pantheon_debate:pd-4161f97adbe7cf2b",
      "pantheon_debate:pd-28e3234b873d0fa1",
      "pantheon_debate:pd-ff28a9ee0255f1ac",
      "pantheon_debate:pd-a757af71f236cd19",
      "pantheon_debate:pd-f7c8e9c9cee30d06",
      "pantheon_debate:pd-9e23c7a2a2ecc48e",
      "pantheon_debate:pd-7e608d078f34bca2",
      "pantheon_debate:pd-a1556dc1ec12950c",
      "pantheon_debate:pd-3814d5425f05e8b8",
      "hypothesis:cc20ae25-3d6c-4ac9-99a2-8dc1f3d75319",
      "hypothesis:27c0b993-f18d-4e32-9bee-e2478772a946"
    ]
  },
  "acceptance_criteria": [
    "Inspect the source artifacts before authoring prose.",
    "Spend compute adaptively based on expected reader value.",
    "Publish at most one daily_brief wiki_page for this topic/date.",
    "Ground every substantive claim in source artifacts.",
    "Record blockers or low-signal deferrals explicitly."
  ],
  "deliverable_refs": [],
  "priority": "normal",
  "state": "requested",
  "roles": [
    "brief_writer",
    "scientific_reviewer"
  ],
  "role_aliases": [],
  "source_policy": "scheduled_worker:brief_writer_daily",
  "source_run_id": "sw-briefwriterd-f80b7d445dfb",
  "source_packet_id": "brief_writer_daily:2026-06-01:general",
  "signals": {
    "topic_delta": 12,
    "max_tokens_hint": 1500,
    "budget_reserved_usd": 1.5,
    "source_artifact_count": 12
  },
  "metadata": {
    "date": "2026-06-01",
    "topic": "general",
    "worker_name": "brief_writer_daily",
    "dispatch_mode": "agent_work_packet",
    "runtime_owner": "scidex-agents",
    "requested_budget": {
      "usd": 1.5
    },
    "budget_accounting": "scheduled_worker budget_usd_used records reserved agent-runtime budget for queued work, not direct substrate LLM spend"
  }
}