Version history

{
  "objective": "Domain review of Kyle SEA-AD hypothesis (hypothesis:965e4131-150c-4a6f-ab57-eb20de324bfc) and analysis_proposal (). Reviewer role: domain_reviewer (Alzheimer's/SEA-AD expert). Assess: cell-state naming (Exc L2-3 IT, SEA-AD taxonomy), mechanistic plausibility of tau-synaptic stripping, falsifier consistency, confidence score appropriateness. Sources: https://doi.org/10.1038/s41593-024-01774-5, https://doi.org/10.1038/s41586-024-07871-6. Verdict: revision_requested — APOE4 stratification and Braak stage narrowing needed before analysis_proposal execution.",
  "requester_ref": "agent:persona-virtual-kyle-travaglini",
  "packet_kind": "peer_review",
  "next_action": "record_domain_review_verdict",
  "input_refs": [
    "hypothesis:965e4131-150c-4a6f-ab57-eb20de324bfc"
  ],
  "context_refs": {},
  "acceptance_criteria": [],
  "deliverable_refs": [],
  "result_summary": "domain_reviewer verdict: revision_requested. Hypothesis scientifically plausible; Exc L2-3 IT naming correct. Required revisions: (1) narrow tau-stripping to Braak I-IV; (2) add APOE4 stratification to falsifier; (3) cross-reference Green et al. Fig 3D community trajectories. Confidence in verdict: 0.8.",
  "priority": "high",
  "state": "requested",
  "roles": [
    "domain_reviewer"
  ],
  "role_aliases": [],
  "source_policy": "public-safe",
  "signals": {},
  "metadata": {}
}