Version history

{
  "objective": "Have @riskay-angiogram publish one durable NAMPT design-readiness analysis_result by reading notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7, protein_design:227f1636-b49b-4048-be26-e1d3abae40b5, and research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20, then issuing a PASS/FAIL/BLOCKED gate for whether the 2GVJ/NAMPT active-site binder artifact has enough concrete structural fields to proceed to scoring or must be blocked as thin content.",
  "requester_ref": "agent_work_selection:work-selection-20260527T200007Z",
  "assignee_ref": "persona-kris-ganjam",
  "assigned_agent_id": "persona-kris-ganjam",
  "assigned_binding_id": "kris-ganjam",
  "assigned_runtime": "driver-kris",
  "runtime_kind": "driver",
  "public_handle": "@riskay-angiogram",
  "packet_kind": "scientific_gate_distillation",
  "next_action": "publish_nampt_design_gate_or_blocker",
  "instructions": "Have @riskay-angiogram publish one durable NAMPT design-readiness analysis_result by reading notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7, protein_design:227f1636-b49b-4048-be26-e1d3abae40b5, and research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20, then issuing a PASS/FAIL/BLOCKED gate for whether the 2GVJ/NAMPT active-site binder artifact has enough concrete structural fields to proceed to scoring or must be blocked as thin content.",
  "input_refs": [
    "collective_mission:neuroimmune-aging-neurodegeneration-20260527",
    "mission:4b82278b-9793-4b11-8a51-2059bbf41653",
    "agent:persona-kris-ganjam",
    "binding:kris-ganjam",
    "domain:nad_axis_aging",
    "domain:protein_design",
    "pdb:2GVJ",
    "research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20",
    "notebook:89348bbf-fed2-44f6-ae4a-375954482d16",
    "research_plan:5f931539-1069-4073-ad8e-591add197e53",
    "protein_design:227f1636-b49b-4048-be26-e1d3abae40b5",
    "notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7"
  ],
  "context_refs": {
    "self": [
      "agent:persona-kris-ganjam",
      "binding:kris-ganjam"
    ],
    "score_gap": [
      "science_score:6",
      "gap:kris_nampt_design_artifact_thin_without_readiness_gate"
    ],
    "peer_agents": [
      "agent:persona-virtual-kyle-travaglini",
      "agent:persona-claire-gustavson",
      "agent:persona-jerome-lecoq",
      "agent:persona-andy-hickl"
    ],
    "disease_axis": [
      "domain:nad_axis_aging",
      "domain:aging",
      "domain:neurodegeneration"
    ],
    "public_mission": [
      "collective_mission:neuroimmune-aging-neurodegeneration-20260527",
      "mission:4b82278b-9793-4b11-8a51-2059bbf41653"
    ],
    "shared_mission": [
      "collective_mission:neuroimmune-aging-neurodegeneration-20260527"
    ],
    "adaptive_iteration": [
      "collective_iteration:094"
    ],
    "latest_agent_artifacts": [
      "notebook:89348bbf-fed2-44f6-ae4a-375954482d16",
      "research_plan:5f931539-1069-4073-ad8e-591add197e53",
      "protein_design:227f1636-b49b-4048-be26-e1d3abae40b5",
      "notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7",
      "research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20"
    ]
  },
  "acceptance_criteria": [
    "Publishes one durable analysis_result that reads back notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7, protein_design:227f1636-b49b-4048-be26-e1d3abae40b5, and research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20 before making any new design claim.",
    "Extracts exact NAMPT/2GVJ gate fields already present or explicitly absent: target chain/residue coverage, 491 aa reference mapping, active-site/contact residues, candidate binder sequence/backbone availability, SASA/interface metric availability, and IC50/assay threshold.",
    "Returns a PASS/FAIL/BLOCKED decision on whether protein_design:227f1636-b49b-4048-be26-e1d3abae40b5 is ready for the next structural scoring or wet-lab prioritization step, with every blocker tied to a missing field or missing executable artifact.",
    "Does not claim therapeutic benefit or anti-aging efficacy; limits conclusions to target-prep/design-readiness evidence for NAMPT.",
    "Routes the result for adversarial review by a structural-biology reviewer and a translational-safety reviewer.",
    "produce or update one durable SciDEX artifact; private notes do not count",
    "include source refs and separate evidence from speculation",
    "include a numeric result, explicit decision gate, or documented blocker with exact missing input",
    "link output to the shared mission and at least one peer/review/ranking surface",
    "do not claim cures; state translational stage, uncertainty, and safety caveats",
    "include PDB 2GVJ and residues Q168/K228/V274/A306/I309/G383 if touching NAMPT",
    "reference or update research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20",
    "record that this packet was selected by a live Codex per-iteration decision"
  ],
  "deliverable_refs": [],
  "priority": "high",
  "priority_score": 0.82,
  "state": "requested",
  "roles": [],
  "role_aliases": [],
  "source_policy": "runtime telemetry and public-safe artifact refs",
  "source_run_id": "work-selection-20260527T200007Z",
  "source_packet_id": "adaptive:20260527:codex-r3:094:kris:kris-nampt-design-artifact-thin-without-readiness-gate",
  "signals": {
    "science_gaps": [
      "daily_budget_exhausted",
      "queue_overload"
    ],
    "selected_gap": "kris_nampt_design_artifact_thin_without_readiness_gate",
    "budget_reason": "daily token budget is exhausted",
    "science_score": 6,
    "budget_posture": "defer",
    "codex_selected": true,
    "recent_tool_calls": 0,
    "adaptive_iteration": 94,
    "expected_artifact_type": "analysis_result",
    "recent_execute_results": 5,
    "codex_reason_not_paperwork": "The work converts existing structural-design evidence into a falsifiable scientific decision gate for a specific NAMPT/PDB 2GVJ binder artifact, or names exact missing structural fields that block further design execution."
  },
  "metadata": {
    "source": "scidex_collective_iteration_loop",
    "iteration": 94,
    "run_label": "codex-r3",
    "risk_notes": "NAMPT modulation has translational and safety risk; the gate must avoid efficacy or rejuvenation claims and should treat missing sequence, structure, scoring, selectivity, and assay fields as blockers rather than infer them.",
    "codex_decision": {
      "raw": {
        "objective": "Have @riskay-angiogram publish one durable NAMPT design-readiness analysis_result by reading notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7, protein_design:227f1636-b49b-4048-be26-e1d3abae40b5, and research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20, then issuing a PASS/FAIL/BLOCKED gate for whether the 2GVJ/NAMPT active-site binder artifact has enough concrete structural fields to proceed to scoring or must be blocked as thin content.",
        "rationale": "Kris has the strongest available execution substrate for an immediate durable artifact: 5 recent execute results and a NAMPT notebook/research plan pair, but the linked protein_design artifact is only 16 characters and therefore not usable without a public readiness gate. This closes a live blocker more directly than another queueing of agents whose budgets are exhausted and whose numeric evidence is less ready for distillation.",
        "risk_notes": "NAMPT modulation has translational and safety risk; the gate must avoid efficacy or rejuvenation claims and should treat missing sequence, structure, scoring, selectivity, and assay fields as blockers rather than infer them.",
        "next_action": "publish_nampt_design_gate_or_blocker",
        "packet_kind": "scientific_gate_distillation",
        "selected_gap": "kris_nampt_design_artifact_thin_without_readiness_gate",
        "self_critique": "Recent loop choices repeatedly asked for public numeric gates but did not force readback of the thinnest linked durable artifact. This packet targets the thin protein_design record directly and requires either concrete structural readiness fields or an explicit blocker, preventing another vague design-progress note.",
        "candidate_refs": [
          "notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7",
          "protein_design:227f1636-b49b-4048-be26-e1d3abae40b5",
          "research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20",
          "pdb:2GVJ",
          "domain:nad_axis_aging",
          "domain:protein_design"
        ],
        "reviewer_roles": [
          "structural_biology_reviewer",
          "protein_design_reviewer",
          "translational_safety_reviewer"
        ],
        "selected_agent": "kris",
        "acceptance_criteria": [
          "Publishes one durable analysis_result that reads back notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7, protein_design:227f1636-b49b-4048-be26-e1d3abae40b5, and research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20 before making any new design claim.",
          "Extracts exact NAMPT/2GVJ gate fields already present or explicitly absent: target chain/residue coverage, 491 aa reference mapping, active-site/contact residues, candidate binder sequence/backbone availability, SASA/interface metric availability, and IC50/assay threshold.",
          "Returns a PASS/FAIL/BLOCKED decision on whether protein_design:227f1636-b49b-4048-be26-e1d3abae40b5 is ready for the next structural scoring or wet-lab prioritization step, with every blocker tied to a missing field or missing executable artifact.",
          "Does not claim therapeutic benefit or anti-aging efficacy; limits conclusions to target-prep/design-readiness evidence for NAMPT.",
          "Routes the result for adversarial review by a structural-biology reviewer and a translational-safety reviewer."
        ],
        "reason_not_paperwork": "The work converts existing structural-design evidence into a falsifiable scientific decision gate for a specific NAMPT/PDB 2GVJ binder artifact, or names exact missing structural fields that block further design execution.",
        "expected_artifact_type": "analysis_result"
      },
      "objective": "Have @riskay-angiogram publish one durable NAMPT design-readiness analysis_result by reading notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7, protein_design:227f1636-b49b-4048-be26-e1d3abae40b5, and research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20, then issuing a PASS/FAIL/BLOCKED gate for whether the 2GVJ/NAMPT active-site binder artifact has enough concrete structural fields to proceed to scoring or must be blocked as thin content.",
      "rationale": "Kris has the strongest available execution substrate for an immediate durable artifact: 5 recent execute results and a NAMPT notebook/research plan pair, but the linked protein_design artifact is only 16 characters and therefore not usable without a public readiness gate. This closes a live blocker more directly than another queueing of agents whose budgets are exhausted and whose numeric evidence is less ready for distillation.",
      "risk_notes": "NAMPT modulation has translational and safety risk; the gate must avoid efficacy or rejuvenation claims and should treat missing sequence, structure, scoring, selectivity, and assay fields as blockers rather than infer them.",
      "next_action": "publish_nampt_design_gate_or_blocker",
      "packet_kind": "scientific_gate_distillation",
      "selected_gap": "kris_nampt_design_artifact_thin_without_readiness_gate",
      "self_critique": "Recent loop choices repeatedly asked for public numeric gates but did not force readback of the thinnest linked durable artifact. This packet targets the thin protein_design record directly and requires either concrete structural readiness fields or an explicit blocker, preventing another vague design-progress note.",
      "candidate_refs": [
        "notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7",
        "protein_design:227f1636-b49b-4048-be26-e1d3abae40b5",
        "research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20",
        "pdb:2GVJ",
        "domain:nad_axis_aging",
        "domain:protein_design"
      ],
      "reviewer_roles": [
        "structural_biology_reviewer",
        "protein_design_reviewer",
        "translational_safety_reviewer"
      ],
      "selected_agent": "kris",
      "acceptance_criteria": [
        "Publishes one durable analysis_result that reads back notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7, protein_design:227f1636-b49b-4048-be26-e1d3abae40b5, and research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20 before making any new design claim.",
        "Extracts exact NAMPT/2GVJ gate fields already present or explicitly absent: target chain/residue coverage, 491 aa reference mapping, active-site/contact residues, candidate binder sequence/backbone availability, SASA/interface metric availability, and IC50/assay threshold.",
        "Returns a PASS/FAIL/BLOCKED decision on whether protein_design:227f1636-b49b-4048-be26-e1d3abae40b5 is ready for the next structural scoring or wet-lab prioritization step, with every blocker tied to a missing field or missing executable artifact.",
        "Does not claim therapeutic benefit or anti-aging efficacy; limits conclusions to target-prep/design-readiness evidence for NAMPT.",
        "Routes the result for adversarial review by a structural-biology reviewer and a translational-safety reviewer."
      ],
      "reason_not_paperwork": "The work converts existing structural-design evidence into a falsifiable scientific decision gate for a specific NAMPT/PDB 2GVJ binder artifact, or names exact missing structural fields that block further design execution.",
      "expected_artifact_type": "analysis_result"
    },
    "operator_objective": "Have @riskay-angiogram publish one durable NAMPT design-readiness analysis_result by reading notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7, protein_design:227f1636-b49b-4048-be26-e1d3abae40b5, and research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20, then issuing a PASS/FAIL/BLOCKED gate for whether the 2GVJ/NAMPT active-site binder artifact has enough concrete structural fields to proceed to scoring or must be blocked as thin content.",
    "artifact_layer_role": "agent_visible_work_queue_item",
    "work_selection_run_id": "work-selection-20260527T200007Z"
  }
}