Objective
Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-fcd38787 and persist valuable results through substrate APIs.
Instructions
You are receiving this as an agent-owned SciDEX work packet, not a fixed substrate LLM loop. Use the cross-disease-analogy and hypothesis-authoring skills. Inspect the source hypothesis, mechanism signatures, candidate target context when supplied, and linked evidence before spending model budget. Spend adaptively: author analogy hypotheses only when the mechanism bridge is plausible, non-duplicative, and testable; defer when the source is too vague or the target mechanism is weak. Expected work: propose up to the policy maximum cross-disease analogy hypotheses in disease verticals different from the source. Persist reviewed outputs through substrate APIs as hypothesis artifacts with metadata kind=cross_disease_analogy, source_hypothesis_id, source_vertical, target_vertical, shared_mechanism, rationale, etl_source=spec_046_cross_disease_analogy, and generator_run_id. If a KG-Jaccard seed is provided, carry kg_jaccard_seeded, kg_jaccard, kg_adjusted_score, seed_target_hypothesis_id, and shared_kg_triples metadata. Do not invent genes/classes not supported by the source or seed context, and do not write directly to substrate storage outside public APIs. Source ref: hypothesis:hypothesis-h-fcd38787 Source title: TGF-β1–SMAD2/3 Axis as Master Suppressor of Microglial Trained Immunity Source disease: unspecified Source vertical: other Source quality_score: 0.711898 Requested analogies: 3 Source signature triples: 0
Acceptance criteria
- Inspect hypothesis:hypothesis-h-fcd38787 and linked context before authoring.
- Use only different target disease verticals from the source.
- Ground every analogy in a plausible shared mechanism.
- Persist only reviewed hypotheses through substrate APIs.
- Record blockers or low-signal deferrals explicitly.
Context
{"artifact_type":"hypothesis","metadata_kind":"cross_disease_analogy","source_vertical":"other","target_vertical":null,"source_hypothesis_ref":"hypothesis:hypothesis-h-fcd38787","seed_target_hypothesis_ref":null}
Selection signals
- Max Tokens Hint
- 1024
- Kg Jaccard Seeded
- false
- Budget Reserved Usd
- 0.5
- Analogies Per Source
- 3
- Source Quality Score
- 0.711898
- Source Signature Size
- 0