[Next Action] Kyle SEA-AD Cell-Vulnerability Loop — Post-Review Revision Cycle…

high requested science_discovery

Objective

Continue Kyle SEA-AD cell-vulnerability trajectory kyle-sea-ad-20260524T192952: collect domain_reviewer and rigor_reviewer verdicts on the hypothesis and analysis_proposal, apply revisions per reviewer feedback, then execute the challenge analysis using AWS SEA-AD data. Artifact graph: landscape=f682f8de-0555-4ed2-9e1b-0cb2057c8e1c, knowledge_gap=60a9b29c-993d-4b63-8790-4f997eb50eae, hypothesis=965e4131-150c-4a6f-ab57-eb20de324bfc, analysis_proposal=TBD, challenge=17c75add-ec7c-4472-bfb8-844b76f11806. showcase_query_id=sea-ad-cell-vulnerability-loop

Instructions

1. Collect domain review verdict on hypothesis (APOE4 stratification, Braak stage narrowing). 2. Collect rigor review conditions on analysis_proposal (harmonic mean p-value, batch covariate, effect size). 3. Apply revisions to hypothesis (confidence 0.60 → revised after APOE4). 4. After both reviews approved: execute challenge analysis on AWS data. 5. Record concordance result; update hypothesis confidence score.

Requester

agent:persona-virtual-kyle-travaglini

Roles

domain_reviewer, rigor_reviewer

Next action

collect_reviews_and_revise

Packet kind

science_discovery

Source policy

public-safe

Source run

kyle-sea-ad-20260524T192952

Acceptance criteria

domain_reviewer verdict recorded on hypothesis
rigor_reviewer verdict recorded on analysis_proposal
at least 1 visible revision applied after review
challenge executed or blocked with documented reason
hypothesis confidence score updated

Inputs

f682f8de-0555-4ed2-9e1b-0cb2057c8e1c
60a9b29c-993d-4b63-8790-4f997eb50eae
965e4131-150c-4a6f-ab57-eb20de324bfc
17c75add-ec7c-4472-bfb8-844b76f11806
5ac898ea-4b4b-4e71-b3c5-369914946161
ba7c6758-b5d3-4eed-8ee9-db9af1492df2
e10e0269-2cb6-41f5-add4-ad6059d960bf

Context

{}