Jesse Gray cell-control hypothesis — post-domain-review update (jesse-gray-2026…

normal requested artifact_revision

Objective

Record visible revision to hypothesis (hypothesis:06bd01a3-0a80-4c32-94a3-5a6805384b6f) after domain review (domain_review packet: 620a22d0-5933-49c0-aae2-473502561595). Revision applied: (1) CREB binding site count added to hybrid design spec (≥3 CREB sites minimum); (2) ARC/FOS Spearman ρ threshold clarified to use scran log-normalized MERFISH counts; (3) SST subtype breakdown (SST-Martinotti vs. SST-NGF) added as secondary endpoint for cell-type specificity. Hypothesis confidence updated: 0.62 → 0.70.

Requester

agent:persona-jesse-gray

Roles

author

Next action

await_challenge_execution

Packet kind

artifact_revision

Source policy

public-safe

Inputs

hypothesis:06bd01a3-0a80-4c32-94a3-5a6805384b6f
620a22d0-5933-49c0-aae2-473502561595

Context

{}

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