Version history

{
  "objective": "Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-var-ce41f0efd7 and persist valuable results through substrate APIs.",
  "requester_ref": "system:cross-disease-analogy",
  "assignee_ref": "role:cross-disease-analogy-generator",
  "packet_kind": "cross_disease_analogy_generation",
  "next_action": "propose_analogy_hypotheses_or_defer",
  "instructions": "You are receiving this as an agent-owned SciDEX work packet, not a fixed substrate LLM loop. Use the cross-disease-analogy and hypothesis-authoring skills. Inspect the source hypothesis, mechanism signatures, candidate target context when supplied, and linked evidence before spending model budget. Spend adaptively: author analogy hypotheses only when the mechanism bridge is plausible, non-duplicative, and testable; defer when the source is too vague or the target mechanism is weak.\n\nExpected work: propose up to the policy maximum cross-disease analogy hypotheses in disease verticals different from the source. Persist reviewed outputs through substrate APIs as hypothesis artifacts with metadata kind=cross_disease_analogy, source_hypothesis_id, source_vertical, target_vertical, shared_mechanism, rationale, etl_source=spec_046_cross_disease_analogy, and generator_run_id. If a KG-Jaccard seed is provided, carry kg_jaccard_seeded, kg_jaccard, kg_adjusted_score, seed_target_hypothesis_id, and shared_kg_triples metadata. Do not invent genes/classes not supported by the source or seed context, and do not write directly to substrate storage outside public APIs.\n\nSource ref: hypothesis:hypothesis-h-var-ce41f0efd7\nSource title: Microglial-Mediated Tau Clearance Dysfunction via TREM2 Signaling\nSource disease: unspecified\nSource vertical: other\nSource quality_score: 0.827143\nRequested analogies: 3\nSource signature triples: 0",
  "input_refs": [
    "hypothesis:hypothesis-h-var-ce41f0efd7"
  ],
  "context_refs": {
    "artifact_type": "hypothesis",
    "metadata_kind": "cross_disease_analogy",
    "source_vertical": "other",
    "target_vertical": null,
    "source_hypothesis_ref": "hypothesis:hypothesis-h-var-ce41f0efd7",
    "seed_target_hypothesis_ref": null
  },
  "acceptance_criteria": [
    "Inspect hypothesis:hypothesis-h-var-ce41f0efd7 and linked context before authoring.",
    "Use only different target disease verticals from the source.",
    "Ground every analogy in a plausible shared mechanism.",
    "Persist only reviewed hypotheses through substrate APIs.",
    "Record blockers or low-signal deferrals explicitly."
  ],
  "deliverable_refs": [],
  "priority": "normal",
  "state": "requested",
  "roles": [
    "cross_disease_analogy_generator",
    "hypothesis_author",
    "scientific_reviewer"
  ],
  "role_aliases": [],
  "source_policy": "scheduled_worker:cross_disease_analogy",
  "source_run_id": "sw-crossdisease-c227ba45ed45",
  "source_packet_id": "cross_disease_analogy:hypothesis:hypothesis-h-var-ce41f0efd7",
  "signals": {
    "seed_candidate": null,
    "max_tokens_hint": 1024,
    "kg_jaccard_seeded": false,
    "budget_reserved_usd": 0.5,
    "analogies_per_source": 3,
    "source_quality_score": 0.827143,
    "source_signature_size": 0
  },
  "metadata": {
    "worker_name": "cross_disease_analogy",
    "dispatch_mode": "agent_work_packet",
    "runtime_owner": "scidex-agents",
    "source_vertical": "other",
    "requested_budget": {
      "usd": 0.5
    },
    "budget_accounting": "scheduled_worker budget_usd_used records reserved agent-runtime budget for queued work, not direct substrate LLM spend",
    "kg_jaccard_seeded": false,
    "source_hypothesis_id": "hypothesis-h-var-ce41f0efd7",
    "source_hypothesis_ref": "hypothesis:hypothesis-h-var-ce41f0efd7"
  }
}