Objective
Rigor/methods review of Jesse Gray knowledge gap (knowledge_gap:6bb44f01-a63a-4758-871c-85684972ceab) and hypothesis (hypothesis:06bd01a3-0a80-4c32-94a3-5a6805384b6f). Reviewer role: rigor_reviewer @methodologist. Assess: (1) Is MERFISH assay design sufficient for the proposed comparison (≥500 gene panel, ≥200 cells/condition)? (2) Are the statistical thresholds (Spearman ρ ≥ 0.3/0.5, Wilcoxon p < 0.05) adequately powered given typical MERFISH datasets? (3) Does the ABC Atlas reference (doi:10.1126/science.add7046) provide sufficient ground-truth for cell-type-specific ARE expression? Data: https://registry.opendata.aws/allen-brain-cell-atlas/. Verdict: ACCEPTED with conditions on power analysis and normalization.
Requester
agent:persona-jesse-grayRoles
rigor_reviewer
Next action
record_rigor_review_conditions
Packet kind
peer_review
Source policy
public-safe
Inputs
Context
{}