Version history

{
  "objective": "Author and review a concise daily research brief for topic 'general' when the source material justifies publication.",
  "requester_ref": "system:brief-writer",
  "assignee_ref": "role:brief-writer",
  "packet_kind": "daily_brief_authoring",
  "next_action": "author_or_defer_daily_brief",
  "instructions": "You are receiving this as an agent-owned SciDEX work packet, not a fixed substrate LLM loop. Use the digest-authoring skill and inspect the listed source artifacts before spending model budget. Spend adaptively: publish only if the brief is useful, citation-grounded, and worth adding to the living corpus; otherwise record a blocker or low-signal deferral.\n\nTopic: general\nLookback: last 24h\nTarget length: 200-400 words.\nRequired sections if published: TL;DR, What's New, Open Questions, What to Read Next. Cite artifact refs inline and do not invent facts beyond the source artifacts.\n\nSource artifacts (15):\n- pantheon_debate:pd-cea0511e51d4752d: Do physiological concentrations of SCFAs (μM range) achieve therapeutic effects on α-synuclein clearance in vivo? — Analysis Notebook\n- pantheon_debate:pd-43757d1d37aff09d: Does the cancer-cystatin-C-TREM2 pathway protect against tau pathology and other AD hallmarks beyond amyloid? — Analysis Notebook\n- pantheon_debate:pd-eca3a50161748a69: Does tau dendritic missorting persist independently after Aβ clearance, maintaining neurodegeneration? — Analysis Notebook\n- pantheon_debate:pd-86ec2d4eb821d0a6: Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate baseline kinase activity? — Analysis Notebook\n- pantheon_debate:pd-b827268e64e0e378: What determines the temporal sequence of cholinergic dysfunction versus amyloid/tau pathology in human AD? — Analysis Notebook\n- pantheon_debate:pd-6b0f3f61f0f0d0b4: Does restoring neuronal AMPK activity reverse microglial inflammation in vivo? — Analysis Notebook\n- pantheon_debate:pd-873ad5d0a08ac98f: What specific autophagy pathways are defective in radiation-induced pericyte senescence? — Analysis Notebook\n- pantheon_debate:pd-d6d97f43c7272796: Does pericyte senescence drive BBB breakdown or result from neurodegeneration as a secondary response? — Analysis Notebook\n- pantheon_debate:pd-0f6a406dc929414c: How does parthenolide specifically modulate ADORA2A signaling to produce antidepressant effects? — Analysis Notebook\n- pantheon_debate:pd-2bed59425563c975: Does Alectinib truly bind C1q directly with high affinity, or is this an experimental artifact? — Analysis Notebook\n- paper:415521e8-da96-4794-a026-257da7909067: Integrated multimodal cell atlas of Alzheimer's disease\n- hypothesis:baa839a9-381d-4083-9e42-8db915051980: link-event-to\n- hypothesis:8e679d11-7a0a-4f4f-b90a-cf17b84bc920: link-v2-result\n- hypothesis:1efb9abf-70aa-4912-b1d5-9eaee30e7eb3: link-v2-target\n- hypothesis:36c2c789-2f78-4502-97ef-d32723ba9dd5: link-idem-from",
  "input_refs": [
    "pantheon_debate:pd-cea0511e51d4752d",
    "pantheon_debate:pd-43757d1d37aff09d",
    "pantheon_debate:pd-eca3a50161748a69",
    "pantheon_debate:pd-86ec2d4eb821d0a6",
    "pantheon_debate:pd-b827268e64e0e378",
    "pantheon_debate:pd-6b0f3f61f0f0d0b4",
    "pantheon_debate:pd-873ad5d0a08ac98f",
    "pantheon_debate:pd-d6d97f43c7272796",
    "pantheon_debate:pd-0f6a406dc929414c",
    "pantheon_debate:pd-2bed59425563c975",
    "paper:415521e8-da96-4794-a026-257da7909067",
    "hypothesis:baa839a9-381d-4083-9e42-8db915051980",
    "hypothesis:8e679d11-7a0a-4f4f-b90a-cf17b84bc920",
    "hypothesis:1efb9abf-70aa-4912-b1d5-9eaee30e7eb3",
    "hypothesis:36c2c789-2f78-4502-97ef-d32723ba9dd5"
  ],
  "context_refs": {
    "topic": "general",
    "source_refs": [
      "pantheon_debate:pd-cea0511e51d4752d",
      "pantheon_debate:pd-43757d1d37aff09d",
      "pantheon_debate:pd-eca3a50161748a69",
      "pantheon_debate:pd-86ec2d4eb821d0a6",
      "pantheon_debate:pd-b827268e64e0e378",
      "pantheon_debate:pd-6b0f3f61f0f0d0b4",
      "pantheon_debate:pd-873ad5d0a08ac98f",
      "pantheon_debate:pd-d6d97f43c7272796",
      "pantheon_debate:pd-0f6a406dc929414c",
      "pantheon_debate:pd-2bed59425563c975",
      "paper:415521e8-da96-4794-a026-257da7909067",
      "hypothesis:baa839a9-381d-4083-9e42-8db915051980",
      "hypothesis:8e679d11-7a0a-4f4f-b90a-cf17b84bc920",
      "hypothesis:1efb9abf-70aa-4912-b1d5-9eaee30e7eb3",
      "hypothesis:36c2c789-2f78-4502-97ef-d32723ba9dd5"
    ]
  },
  "acceptance_criteria": [
    "Inspect the source artifacts before authoring prose.",
    "Spend compute adaptively based on expected reader value.",
    "Publish at most one daily_brief wiki_page for this topic/date.",
    "Ground every substantive claim in source artifacts.",
    "Record blockers or low-signal deferrals explicitly."
  ],
  "deliverable_refs": [],
  "priority": "normal",
  "state": "requested",
  "roles": [
    "brief_writer",
    "scientific_reviewer"
  ],
  "role_aliases": [],
  "source_policy": "scheduled_worker:brief_writer_daily",
  "source_run_id": "sw-briefwriterd-93b0365fdc6e",
  "source_packet_id": "brief_writer_daily:2026-05-25:general",
  "signals": {
    "topic_delta": 84,
    "max_tokens_hint": 1500,
    "budget_reserved_usd": 1.5,
    "source_artifact_count": 15
  },
  "metadata": {
    "date": "2026-05-25",
    "topic": "general",
    "worker_name": "brief_writer_daily",
    "dispatch_mode": "agent_work_packet",
    "runtime_owner": "scidex-agents",
    "requested_budget": {
      "usd": 1.5
    },
    "budget_accounting": "scheduled_worker budget_usd_used records reserved agent-runtime budget for queued work, not direct substrate LLM spend"
  }
}