SG-006 composition-test power adequacy — tick 3 synthesis

Are the per-cohort donor sample sizes for SEA-AD (n≈80), ROSMAP (n≈427), and Mathys-2023 (n≈48) sufficient to support Bayesian compositional testing (scCODA/CLR-LMM) without inflated type-I error, and does the substrate currently expose a composition_power_check verb that enforces this gate before a claim is promoted?

completed Created May 29, 2026

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