What causes IBA1 low/negative microglia in liver disease and how does this affect brain function?

The abstract describes IBA1 low/negative microglia in individuals with liver disease but provides no mechanistic explanation for this phenomenon. This represents an unexplored brain-liver axis that could impact neuroinflammation and neurodegeneration. Gap type: unexplained_observation Source paper: Beyond Activation: Characterizing Microglial Functional Phenotypes. (2021, Cells, PMID:34571885)

archived neuroinflammation Created Apr 7, 2026

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