Do chaperones selectively recognize pathological vs physiological protein conformations?

The debate revealed fundamental uncertainty about whether HSP70/HSP90 systems can distinguish pathological seeds from normal misfolded intermediates. This selectivity is crucial for therapeutic reprogramming strategies but remains mechanistically unclear. Source: Debate session sess_SDA-2026-04-08-gap-pubmed-20260406-062207-b800e5d3 (Analysis: SDA-2026-04-08-gap-pubmed-20260406-062207-b800e5d3)

archived protein biochemistry Created Apr 10, 2026

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