Do tau-specific HSP90 conformational states exist that differ from other client protein complexes?

The debate hinged on whether HSP90 adopts unique conformations when bound to tau versus other clients, but no structural evidence was provided. This fundamental question determines whether allosteric tau-selective inhibitors are even theoretically possible. Source: Debate session sess_SDA-2026-04-10-SDA-2026-04-09-gap-debate-20260409-201742-5407d57d (Analysis: SDA-2026-04-09-gap-debate-20260409-201742-5407d57d)

archived structural biology Created Apr 10, 2026

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