What delivery mechanisms can achieve therapeutically relevant CRISPR concentrations across the blood-brain barrier at scale?

All participants identified BBB penetration as a critical bottleneck, but no existing delivery system (AAV, LNPs) achieves sufficient brain distribution for clinical efficacy. This remains the primary translational barrier. Source: Debate session sess_SDA-2026-04-02-gap-crispr-neurodegeneration-20260402 (Analysis: SDA-2026-04-02-gap-crispr-neurodegeneration-20260402)

archived drug delivery Created Apr 10, 2026

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