Do SPM receptors undergo desensitization with chronic agonist treatment, preventing therapeutic priming?

The debate highlighted receptor desensitization as a critical concern for SPM receptor priming therapy, but no definitive data exists on whether ALX/FPR2 and GPR32 follow typical GPCR desensitization patterns. This fundamental question determines the viability of chronic priming approaches. Source: Debate session sess_sda-2026-04-01-gap-014 (Analysis: sda-2026-04-01-gap-014)

archived pharmacology Created Apr 11, 2026

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