What brain concentrations of SCFAs are achieved via oral probiotics and are they sufficient for therapeutic HDAC inhibition?

The debate highlighted that while SCFAs can cross the blood-brain barrier, the actual brain concentrations reached through probiotic administration remain unknown. This is critical for determining whether gut-derived SCFAs can achieve therapeutic levels for microglial reprogramming. Source: Debate session sess_sda-2026-04-01-003 (Analysis: sda-2026-04-01-003)

archived pharmacokinetics Created Apr 11, 2026

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