What determines blood-brain barrier penetration kinetics for specialized pro-resolving mediators?

The debate highlighted BBB penetration as a major hurdle for SPM therapeutics but provided no mechanistic understanding of transport barriers. This knowledge gap prevents rational design of CNS-penetrant pro-resolving mediators. Source: Debate session sess_SDA-2026-04-01-gap-014 (Analysis: SDA-2026-04-01-gap-014)

archived neuropharmacology Created Apr 13, 2026

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