Human connectome alterations in Alzheimer's disease: structural and functional network disintegration

How does the human brain connectome reorganize in Alzheimer's disease, and what are the vulnerable hub regions that drive network-wide disintegration? Does connectome breakdown precede or follow amyloid/tau pathology, and can graph-theoretic measures of connectome integrity serve as early biomarkers of neurodegeneration?

completed connectomics Created Apr 16, 2026

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