How does lncRNA-0021 achieve sequence-specific binding to mmu-miR-6361 and what determines this selectivity?

The study demonstrates direct binding between lncRNA-0021 and miR-6361 as the key ceRNA mechanism, but doesn't explain the molecular basis for this specific interaction. Understanding binding specificity is crucial for designing targeted RNA therapeutics and predicting off-target effects. Gap type: unexplained_observation Source paper: hUC-MSC-derived exosomes ameliorate Alzheimer's disease pathology through lncRNA-9969-mediated multi-target protection involving neuronal autophagy and microglial modulation. (2026, Alzheimer's research & therapy, PMID:41540476)

completed molecular neurobiology Created Apr 25, 2026

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