Power envelope audit: SEA-AD (n=84) and ROSMAP (n=420) under Dirichlet-multinomial composition model

What is the minimum detectable cell-type proportion shift (MDS) achievable at 80% and 90% power under a Dirichlet-multinomial model for SEA-AD (n=84 donors) versus ROSMAP (n=420 donors), stratified across an effect-size grid of 0.01–0.20 at FDR thresholds 0.05 and 0.10, and does SEA-AD cross the MDS threshold for rare cell types (<5% mean abundance) at a 5 percentage-point shift?

pending Created May 27, 2026

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