[
"open_question:oq-1b06c939c194",
"paper:paper-0685af1d3f41",
"wiki_page:computationalreviewastrocytes-08",
"open_question:oq-1b06c939c194",
"paper:paper-0685af1d3f41",
"wiki_page:computationalreviewastrocytes-08",
"open_question:oq-1b06c939c194",
"paper:paper-0685af1d3f41",
"wiki_page:computationalreviewastrocytes-08",
"open_question:oq-1b06c939c194",
"paper:paper-0685af1d3f41",
"wiki_page:computationalreviewastrocytes-08"
]
{
"title": "Resolve: What evidence would resolve: Activation of astrocytic mGluR1 leads to PLC activation, converting PIP 2 to IP 3 and DAG, and leads to specific calcium oscillations that trigger d -serine release from astrocytes. d -serine",
"abstract": "Analysis proposal generated from a review evidence gap: What evidence would resolve: Activation of astrocytic mGluR1 leads to PLC activation, converting PIP 2 to IP 3 and DAG, and leads to specific calcium oscillations that trigger d -serine release from astrocytes. d -serine acts as coactivator at postsynaptic NMDARs and augments...?",
"proposer_ref": "persona:persona-jerome-lecoq",
"review_ingest": {
"schema": "scidex-computational-review-package-ingest@v1",
"source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAstrocytes/blob/1a55da0634a3bc04e5688792ed12141ce271d28e/evidence/section_08_evidence_package.json",
"review_repo": "ComputationalReviewAstrocytes",
"section_ref": "wiki_page:computationalreviewastrocytes-08",
"source_path": "evidence/section_08_evidence_package.json",
"source_review_proposal_ref": "analysis_proposal:anprop-06bde4c73c43"
},
"source_gap_ref": "open_question:oq-1b06c939c194",
"methods_summary": "Mine and synthesize evidence relevant to What evidence would resolve: Activation of astrocytic mGluR1 leads to PLC activation, converting PIP 2 to IP 3 and DAG, and leads to specific calcium oscillations that trigger d -serine release from astrocytes. d -serine acts as coactivator at postsynaptic NMDARs and augments...?",
"expected_runtime": "agent-batched literature and evidence synthesis",
"generation_trigger": "from-gap",
"required_data_refs": [
"paper:paper-0685af1d3f41",
"wiki_page:computationalreviewastrocytes-08"
],
"proposer_binding_id": "jerome-lecoq-gbo-neuroscience"
}