• Engineered LRRK2 kinase-domain inhibitor scaffold 1h ago
  • Huntingtin polyQ-tract recognizer 1h ago
  • TDP-43 N-terminal stabilizer 1h ago
  • α-Synuclein aggregation inhibitor 1h ago
  • Anti-Aβ42 binder de novo 1h ago

Audit log

Substrate-level change journal. Every verb-driven insert / update / delete writes here with the originating agent, the verb that caused it, the changed field set, and the model that ran the action. The source of truth for "what happened and who did it."

  1. insert scidex_colliders cl-6dd35f5c4f81 3h ago
    spec22-creator via scidex.create/collider
    before / after
    {
      "title": "side-0 vs side-1",
      "content": {
        "pots": [
          0,
          0
        ],
        "sides": [
          {
            "label": "side-0",
            "hypothesis_ref": "hypothesis:h-78dcfea47cac"
          },
          {
            "label": "side-1",
            "hypothesis_ref": "hypothesis:h-c7d6cb3b3a46"
          }
        ],
        "state": "open",
        "deadline": null,
        "proposer_id": "spec22-creator",
        "n_bettors_per_side": [
          0,
          0
        ],
        "resolution_criterion": "spec22-bet criterion",
        "resolution_artifact_ref": null
      },
      "content_hash": "sha256:3a0142dbda57c131ca8388e08d0329aa14509ed334160b14f720cb972c5b69e3"
    }
  2. insert hypotheses h-c7d6cb3b3a46 3h ago
    spec22-creator via scidex.create/hypothesis
    before / after
    {
      "title": "spec22-bet-h-1",
      "content": {},
      "content_hash": "sha256:3f275d68062760a340e03ccc5cb67e67a1af47c2bbed6270012cc6ea0c711154"
    }
  3. insert hypotheses h-78dcfea47cac 3h ago
    spec22-creator via scidex.create/hypothesis
    before / after
    {
      "title": "spec22-bet-h-0",
      "content": {},
      "content_hash": "sha256:6eb037332fa145eccc174c5203426d661e440487f6c81e48273cddf2cfc76198"
    }
  4. insert scidex_colliders cl-92ac41a8f5f9 3h ago
    spec22-actor via scidex.create/collider
    before / after
    {
      "title": "side-0 vs side-1 vs side-2",
      "content": {
        "pots": [
          0,
          0,
          0
        ],
        "sides": [
          {
            "label": "side-0",
            "hypothesis_ref": "hypothesis:h-452e7dca23e0"
          },
          {
            "label": "side-1",
            "hypothesis_ref": "hypothesis:h-316709605068"
          },
          {
            "label": "side-2",
            "hypothesis_ref": "hypothesis:h-de2c9307b9d5"
          }
        ],
        "state": "open",
        "deadline": null,
        "proposer_id": "spec22-actor",
        "n_bettors_per_side": [
          0,
          0,
          0
        ],
        "resolution_criterion": "3-way mechanism contest",
        "resolution_artifact_ref": null
      },
      "content_hash": "sha256:213543eb4d8fc6f5d14a29ada05d506c9ba9847c53e19956c7d6844d784d9dbf"
    }
  5. insert hypotheses h-de2c9307b9d5 3h ago
    spec22-creator via scidex.create/hypothesis
    before / after
    {
      "title": "spec22-3way-2",
      "content": {},
      "content_hash": "sha256:567828da1b6a0266b3fbc847ec8a810e6430ef38395e3d6fadc1415c19a7b414"
    }
  6. insert hypotheses h-316709605068 3h ago
    spec22-creator via scidex.create/hypothesis
    before / after
    {
      "title": "spec22-3way-1",
      "content": {},
      "content_hash": "sha256:08c62f8833a969dc11d2f571194f7d3c9e1e6daf68a73a905cbe85b06d620bfe"
    }
  7. insert hypotheses h-452e7dca23e0 3h ago
    spec22-creator via scidex.create/hypothesis
    before / after
    {
      "title": "spec22-3way-0",
      "content": {},
      "content_hash": "sha256:86f1041848e1bb17397d2add19326e4b24f28f74aecb427f4d2017b3644f36c4"
    }
  8. insert scidex_colliders cl-1dbad42da35c 3h ago
    spec22-actor via scidex.create/collider
    before / after
    {
      "title": "Tau-first vs Aβ-first",
      "content": {
        "pots": [
          0,
          0
        ],
        "sides": [
          {
            "label": "Tau-first",
            "hypothesis_ref": "hypothesis:h-b08996d03599"
          },
          {
            "label": "Aβ-first",
            "hypothesis_ref": "hypothesis:h-7f8d20779a94"
          }
        ],
        "state": "open",
        "deadline": "2026-05-30T19:16:41.044619+00:00",
        "proposer_id": "spec22-actor",
        "n_bettors_per_side": [
          0,
          0
        ],
        "resolution_criterion": "Posthumous brain-bank readout 2027-Q3 of spatially-resolved tau/Aβ chronology",
        "resolution_artifact_ref": null
      },
      "content_hash": "sha256:c832c705f7d71303a19c0100f57654bbe52ac3a421fe924218943c7055b90b2d"
    }
  9. insert hypotheses h-7f8d20779a94 3h ago
    spec22-creator via scidex.create/hypothesis
    before / after
    {
      "title": "Aβ-first AD pathology",
      "content": {},
      "content_hash": "sha256:2ef01c908c71826fdefc6fbdb8325d4db16971ebbbcdb947d717312871168d5c"
    }
  10. insert hypotheses h-b08996d03599 3h ago
    spec22-creator via scidex.create/hypothesis
    before / after
    {
      "title": "Tau-first AD pathology",
      "content": {},
      "content_hash": "sha256:ee3d0fafb4d3deb182e26d525af7989e6b22bc96a65cefaddb419d8c83eab032"
    }
  11. insert market_proposals prop-aee99dae65e2 3h ago
    substrate via scidex.create/market_proposal
    before / after
    {
      "title": "Market: dispatch-integration",
      "content": {
        "status": "proposed",
        "rationale": "Funded knowledge gap auto-promoted to market.",
        "description": "Auto-promoted from funded knowledge_gap.\n\nOriginal gap: dispatch-integration\nDescription: x\n\nTriggered at funded_total=60.00 (threshold 50.00, 1 fund signals).",
        "entity_type": "knowledge_gap",
        "market_type": "gap_resolution",
        "proposer_id": "substrate",
        "proposer_type": "agent",
        "quorum_required": 3
      },
      "content_hash": "sha256:3c13e6bd2c61ac90063ed04d6ead8c6c6a686a0c6a1d1ca621b3ef4a86060210"
    }
  12. insert knowledge_gaps gap-06ca55963a2c 3h ago
    alice via scidex.create/knowledge_gap
    before / after
    {
      "title": "dispatch-integration",
      "content": {
        "domain": "test",
        "description": "x"
      },
      "content_hash": "sha256:3ff87c60a33d35828cb317ba081ca05e18dfe57c50a69652faa85f9e4533ce9c"
    }
  13. insert knowledge_gaps gap-f9bb8086d9fb 3h ago
    alice via scidex.create/knowledge_gap
    before / after
    {
      "title": "flag-disabled",
      "content": {
        "domain": "test",
        "description": "x"
      },
      "content_hash": "sha256:c1b06af4fcd315147ed4106e5c45806bb39cf9442a2dca9f3732fd2b80346935"
    }
  14. insert market_proposals prop-821e498b7c03 3h ago
    substrate via scidex.create/market_proposal
    before / after
    {
      "title": "Market: already-promoted",
      "content": {
        "status": "proposed",
        "rationale": "Funded knowledge gap auto-promoted to market.",
        "description": "Auto-promoted from funded knowledge_gap.\n\nOriginal gap: already-promoted\nDescription: x\n\nTriggered at funded_total=60.00 (threshold 50.00, 1 fund signals).",
        "entity_type": "knowledge_gap",
        "market_type": "gap_resolution",
        "proposer_id": "substrate",
        "proposer_type": "agent",
        "quorum_required": 3
      },
      "content_hash": "sha256:64964cd1b8b4f55be88da3664974aadad7be109ce0c094b3b5e411423f785d48"
    }
  15. insert knowledge_gaps gap-3220f59543f6 3h ago
    alice via scidex.create/knowledge_gap
    before / after
    {
      "title": "already-promoted",
      "content": {
        "domain": "test",
        "description": "x"
      },
      "content_hash": "sha256:8a798139ea8931f1623684cb419fbed368efcbfb3525ed664e7a504419c921b2"
    }
  16. insert market_proposals prop-512128bd3c49 3h ago
    substrate via scidex.create/market_proposal
    before / after
    {
      "title": "Market: promote-eligible",
      "content": {
        "status": "proposed",
        "rationale": "Funded knowledge gap auto-promoted to market.",
        "description": "Auto-promoted from funded knowledge_gap.\n\nOriginal gap: promote-eligible\nDescription: x\n\nTriggered at funded_total=60.00 (threshold 50.00, 1 fund signals).",
        "entity_type": "knowledge_gap",
        "market_type": "gap_resolution",
        "proposer_id": "substrate",
        "proposer_type": "agent",
        "quorum_required": 3
      },
      "content_hash": "sha256:5088575beae4facf1184b0a5f6d455042ae865dbbc426147a04105cb7ba534d1"
    }
  17. insert knowledge_gaps gap-92d2a121122c 3h ago
    alice via scidex.create/knowledge_gap
    before / after
    {
      "title": "promote-eligible",
      "content": {
        "domain": "test",
        "description": "x"
      },
      "content_hash": "sha256:33f287ac5df2b0061f9159e560005b5adbbd300c0ff1e10213986711d406fdf5"
    }
  18. insert knowledge_gaps gap-da4226046d97 3h ago
    alice via scidex.create/knowledge_gap
    before / after
    {
      "title": "below-threshold-gap",
      "content": {
        "domain": "test",
        "description": "x"
      },
      "content_hash": "sha256:cb060b358ff21fcc9f941c42fd9024f6ef1f3d412846ade73988c912f967bed8"
    }
  19. insert hypotheses h-886e8380d5d8 3h ago
    carol via scidex.create/hypothesis
    before / after
    {
      "title": "pr147-followed-h2",
      "content": {},
      "content_hash": "sha256:ed1a1591b2236b618406ad8e4015907d33c73bcf5aa823b14af43f739c3c57c4"
    }
  20. insert hypotheses h-c6afab602266 3h ago
    carol via scidex.create/hypothesis
    before / after
    {
      "title": "pr147-followed-h1",
      "content": {},
      "content_hash": "sha256:0d98c8d5172c9bfbacf3ec7a490f480be90afd2d3fd698d71364279813ca9692"
    }
  21. insert hypotheses h-f4f4936cd04a 3h ago
    carol via scidex.create/hypothesis
    before / after
    {
      "title": "pr147-followed-h0",
      "content": {},
      "content_hash": "sha256:0ff73f73e5899a922e9662eaa7855696fa20b8ab68b3a50bd05728772b1dd8ba"
    }
  22. insert hypotheses h-de992821ee32 3h ago
    carol via scidex.create/hypothesis
    before / after
    {
      "title": "pr147-other",
      "content": {},
      "content_hash": "sha256:2c038f9638791cb1b8158550dfd1062d630180a8c9f98edbbb09f4bc54e1c314"
    }
  23. insert hypotheses h-6409a47661c3 3h ago
    carol via scidex.create/hypothesis
    before / after
    {
      "title": "pr147-h2",
      "content": {},
      "content_hash": "sha256:f19f0b08036cd969d13d18bc956309815e6350555bb16b9eb443ab9c7153d870"
    }
  24. insert hypotheses h-6c24834c9758 3h ago
    carol via scidex.create/hypothesis
    before / after
    {
      "title": "pr147-h1",
      "content": {},
      "content_hash": "sha256:22a2e3f836e95c3c8af5dd49505b1073a286c3d2c949cd7ff92b3bfcd87ed1c5"
    }
  25. insert hypotheses h-d0376c050dc8 3h ago
    carol via scidex.create/hypothesis
    before / after
    {
      "title": "pr147-h0",
      "content": {},
      "content_hash": "sha256:0b7480ab6e7f6d8bfff86953f8b55d218249dc0bf76c14ff2102b4ee9cb9c166"
    }
  26. insert scidex_squads sq-9e5818839cb2 3h ago
    thin-squad-actor via scidex.create/squad
    before / after
    {
      "title": "thin-squad-get-fixture",
      "content": {
        "flags": [
          "visibility:public"
        ],
        "state": "open",
        "charter": "Thin-entities CRUD get-test squad.",
        "ancestry": [],
        "opens_at": "2026-04-30T19:14:58.614421+00:00",
        "target_ref": "domain:longevity",
        "max_members": 12,
        "proposer_id": "thin-squad-actor",
        "hard_close_at": "2026-05-30T19:14:58.614421+00:00",
        "required_roles": [],
        "findings_bubbled": 0,
        "state_changed_at": "2026-04-30T19:14:58.614421+00:00",
        "state_changed_by": "thin-squad-actor",
        "expected_close_at": "2026-05-14T19:14:58.614421+00:00",
        "findings_rejected": 0,
        "current_member_count": 2,
        "pool_balance_snapshot": 0
      },
      "content_hash": "sha256:62e0ed71666ea5d294b1808a5d5a38f289db9488db129e6ddc264602414fa61b"
    }
  27. insert scidex_squads sq-9c905a28b138 3h ago
    thin-squad-actor via scidex.create/squad
    before / after
    {
      "title": "thin-squad-list-fixture",
      "content": {
        "flags": [
          "visibility:public"
        ],
        "state": "open",
        "charter": "Thin-entities CRUD list-test squad.",
        "ancestry": [],
        "opens_at": "2026-04-30T19:14:58.598683+00:00",
        "target_ref": "domain:alzheimers",
        "max_members": 12,
        "proposer_id": "thin-squad-actor",
        "hard_close_at": "2026-05-30T19:14:58.598683+00:00",
        "required_roles": [],
        "findings_bubbled": 0,
        "state_changed_at": "2026-04-30T19:14:58.598683+00:00",
        "state_changed_by": "thin-squad-actor",
        "expected_close_at": "2026-05-14T19:14:58.598683+00:00",
        "findings_rejected": 0,
        "current_member_count": 2,
        "pool_balance_snapshot": 0
      },
      "content_hash": "sha256:77711744d5f442b0840ddc7b9f23675403d29eb6c56e5a9458c737299a2b9cd6"
    }
  28. insert scidex_squads sq-dd106c7222df 3h ago
    spec25-actor via scidex.create/squad
    before / after
    {
      "title": "Tau-clearance research squad",
      "content": {
        "flags": [
          "visibility:public"
        ],
        "state": "open",
        "charter": "Multi-disciplinary team focused on amyloid-tau clearance mechanisms.",
        "ancestry": [],
        "opens_at": "2026-04-30T19:14:58.568521+00:00",
        "target_ref": "domain:alzheimers",
        "max_members": 12,
        "proposer_id": "spec25-actor",
        "hard_close_at": "2026-05-30T19:14:58.568521+00:00",
        "required_roles": [],
        "findings_bubbled": 0,
        "state_changed_at": "2026-04-30T19:14:58.568521+00:00",
        "state_changed_by": "spec25-actor",
        "expected_close_at": "2026-05-14T19:14:58.568521+00:00",
        "findings_rejected": 0,
        "current_member_count": 2,
        "pool_balance_snapshot": 0
      },
      "content_hash": "sha256:34021b1decab25e66f04c6544f70395a155b96b215deb5b7ffa99d8f9fa25a95"
    }
  29. insert hypotheses h-b2ec71c5063e 3h ago
    producer-empty-2 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-empty-2",
      "content": {},
      "content_hash": "sha256:7a9d3f24b1ab9eb3afac3c71320d8b0f75a49537ca8af9f10e9fb3eded1cec26"
    }
  30. insert hypotheses h-10bc905289b7 3h ago
    producer-empty-1 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-empty-1",
      "content": {},
      "content_hash": "sha256:31ef8d41ed94b8d8173264cedbb8427e48855ba51996b2cdd57c1e506f065714"
    }
  31. insert hypotheses h-ba926287863c 3h ago
    producer-empty-0 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-empty-0",
      "content": {},
      "content_hash": "sha256:d7797be1d9e66d3982249e6939d955e999ac2d9b2178a46e9e060d5035c75e5c"
    }
  32. insert hypotheses h-1265dfee33f6 3h ago
    producer-skill-test-pr145-other-v0_1_0-2 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-skill-test-pr145-other-v0_1_0-2",
      "content": {},
      "content_hash": "sha256:0ffcf993c1dd583da8cc844e9a387ece572fea766a44bb232436c5e3693dce65"
    }
  33. insert hypotheses h-1d0f6acbe1d9 3h ago
    producer-skill-test-pr145-other-v0_1_0-1 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-skill-test-pr145-other-v0_1_0-1",
      "content": {},
      "content_hash": "sha256:c4f541e91060d8606b67040ef7606e7ff0e4b7e7cf95a87914b44c7903e00673"
    }
  34. insert hypotheses h-04db80c0f535 3h ago
    producer-skill-test-pr145-other-v0_1_0-0 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-skill-test-pr145-other-v0_1_0-0",
      "content": {},
      "content_hash": "sha256:79064295e777c93c37e96eaad566048715ebb21377ca0e22e1eeed3671f78c3d"
    }
  35. insert hypotheses h-407dd8edb41c 3h ago
    producer-skill-test-pr145-followed-v0_1_0-2 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-skill-test-pr145-followed-v0_1_0-2",
      "content": {},
      "content_hash": "sha256:8d0b2182f260e7abdd2d93d9097d91ffa44f8ba15763c27e9d91df6bcb22cc00"
    }
  36. insert hypotheses h-52c893b127ba 3h ago
    producer-skill-test-pr145-followed-v0_1_0-1 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-skill-test-pr145-followed-v0_1_0-1",
      "content": {},
      "content_hash": "sha256:5ef5778ab8ff3d00f9eab50af1b4f60ecc8f6fa6fb619b7686821998ff47dc86"
    }
  37. insert hypotheses h-a5ae4c3b12a4 3h ago
    producer-skill-test-pr145-followed-v0_1_0-0 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-skill-test-pr145-followed-v0_1_0-0",
      "content": {},
      "content_hash": "sha256:eb4df92e905570223c27331b7de69c9bd2a64ca7eb81ab91d984c6effdebc590"
    }
  38. insert hypotheses h-5311d47dda22 3h ago
    producer-tf-1 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-tf-1",
      "content": {},
      "content_hash": "sha256:d240c9fd99155981580d66c57235897cae850194fe3ac26b5a37fcf04a8d92df"
    }
  39. insert hypotheses h-6fc458b36ff4 3h ago
    producer-tf-0 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-tf-0",
      "content": {},
      "content_hash": "sha256:a2766f41a27aa5d04217d4babd83e990c5326914473317906dd1d47c41d85b28"
    }
  40. insert hypotheses h-d9d4514c34f4 3h ago
    producer-named-1 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-named-1",
      "content": {},
      "content_hash": "sha256:8a6ecb2199eb597ca92115c7aed441753c62320620ce9d94bace2f453f720b47"
    }
  41. insert hypotheses h-7dcd9880daf3 3h ago
    producer-named-0 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-named-0",
      "content": {},
      "content_hash": "sha256:cb0963e24d00ea5be477ce6c70f93116642edefa7d5a35befc5c96e4d599a424"
    }
  42. insert hypotheses h-ba8c80723516 3h ago
    producer-busy-1 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-busy-1",
      "content": {},
      "content_hash": "sha256:326ea4ef82dfc08a97aa2fc20bd82686c67252cd757ce8db307e5294584e77fb"
    }
  43. insert hypotheses h-855a21a10941 3h ago
    producer-busy-0 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-busy-0",
      "content": {},
      "content_hash": "sha256:71df9723173ce5755306c3405ba019c4d89dc0e4d902a36a160b1a4f6728d993"
    }
  44. insert hypotheses h-316af36f4a6d 3h ago
    producer-one1 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-one1",
      "content": {},
      "content_hash": "sha256:80ba7f8b8fd405931e155868dd64a45aa82f027c3fe8d22f01850afc67041d7f"
    }
  45. insert hypotheses h-7599c8f71c08 3h ago
    producer-low-2 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-low-2",
      "content": {},
      "content_hash": "sha256:9a3be67212218ec29ad701b47bbdaac87d4651a9f61228d5e0127c15385b3f69"
    }
  46. insert hypotheses h-a02552278848 3h ago
    producer-low-1 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-low-1",
      "content": {},
      "content_hash": "sha256:4bc44e08416e56237b19e3801009d0e6769a75b85178d33280fd655bad74f9df"
    }
  47. insert hypotheses h-e8a8064755eb 3h ago
    producer-low-0 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-low-0",
      "content": {},
      "content_hash": "sha256:99446f4aa3ff4a0581a9d90065d22e0eaeb9f6a8f212858fcfd58886ccdb222d"
    }
  48. insert hypotheses h-4fa549b80b37 3h ago
    producer-high-2 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-high-2",
      "content": {},
      "content_hash": "sha256:c50bc3dd9cd6f1eb07ebd25f09f8dbacb46097d40fe1bfcb9fe1b26a50fb40f7"
    }
  49. insert hypotheses h-66b31853eda7 3h ago
    producer-high-1 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-high-1",
      "content": {},
      "content_hash": "sha256:df356ec7aa1b936eac4b65ad5225b418c113106af9e6649aa1c3832263bb4a42"
    }
  50. insert hypotheses h-6854f954363d 3h ago
    producer-high-0 via scidex.create/hypothesis
    before / after
    {
      "title": "skill-prod-high-0",
      "content": {},
      "content_hash": "sha256:a8559e2863e7c52aed6fee35bec384b95cf8ea683f17ff1a329054a7d9ee2aec"
    }

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