Version history

{
  "description": "Falsifiable prediction from high-scoring hypothesis (score=0.723, gene=GRIN2B). Hypothesis: Does enhancing GluN2B-containing NMDA receptor activity at cortico-striatal synapses restore 30-40 Hz beta-band synchrony and improve motor sequence learning in early Huntington's disease? Success criteria: 1. GRIN2B activity enhancement (CIQ or similar) increases 30-40 Hz LFP power in striatum by >40% in HD model mice. 2. Motor sequence learning (accelerating rotarod) improves by >25% in treated HD mice vs vehicle. 3. Striatal medium spiny neuron (MSN) firing regularity (interspike interval CV) normalizes to within 20% of WT. 4. No excitotoxicity: caspase-3+ neurons remain <5% in treated vs vehicle HD mice.",
  "challenge_type": "hypothesis_resolve",
  "scope": "single_target",
  "initial_bounty_usd": 500,
  "current_bounty_usd": 500,
  "bounty_confidence": 0.5,
  "market_price": 0.5,
  "composite_score": 0.723,
  "debate_count": 0,
  "status": "open",
  "question": "Does enhancing GluN2B-containing NMDA receptor activity at cortico-striatal synapses restore 30-40 Hz beta-band synchrony and improve motor sequence learning in early Huntington's disease?",
  "domain": "neurodegeneration",
  "triggered_by": "hypothesis-auto-create"
}