Version history

{
  "description": "This challenge targets the hypothesis: **Direct Toxicity Hypothesis: β-Amyloid Directly Impairs Cholinergic Signaling**\n\n**Hypothesis Summary:** ## Mechanistic Overview\nDirect Toxicity Hypothesis: β-Amyloid Directly Impairs Cholinergic Signaling starts from the claim that modulating CHRNA7, CHRM1 within the disease context of neurodegeneration can redirect a disease-relevant process. The original description reads: \"# Direct Toxicity Hypothesis: β-Amyloid Directly Impairs Cholinergic Signaling ## Mechanistic Overview The Direct Toxicity Hypothesis proposes that soluble β-amyloid (Aβ) oligomers exert their pathogenic effects on cholinergi\n\n**Falsifiable Predictions:**\n1. Pharmacological modulation of CHRNA7 will alter neurodegeneration markers in validated models by ≥20%\n2. Genetic knockdown of the key target will reproduce the pathological phenotype in ≥2 independent model systems\n3. Patient-derived biosamples will show the predicted molecular signature (sensitivity ≥70%, specificity ≥70%)\n4. Mechanistic intervention at the proposed node will rescue neuronal viability in vitro by ≥30%\n\n**Bounty Tier:** $126,900 USD (composite score 0.769)\n**Challenge Type:** Open — any team may submit experimental evidence supporting or refuting this hypothesis\n\n**Success Criteria:** Peer-reviewed evidence demonstrating mechanistic validation of ≥2 of the 4 predictions, with independent replication.",
  "mission_id": "neurodegeneration",
  "challenge_type": "open",
  "scope": "hypothesis",
  "initial_bounty_usd": 126900,
  "current_bounty_usd": 126900,
  "bounty_confidence": 0.7,
  "gap_importance_score": 0.769,
  "urgency_score": 0.6,
  "market_price": 0.5,
  "composite_score": 0.692,
  "debate_count": 0,
  "status": "open",
  "domain": "neurodegeneration"
}