Version history

{
  "description": "Falsifiable prediction from high-scoring hypothesis (score=0.720, gene=VCP). Hypothesis: Do VCP/p97 mutations (common in IBMPFD/ALS) impair extraction of ubiquitinated autophagy substrates, causing proteasome-autophagy flux obstruction, and does VCP activation restore this flux? Success criteria: 1. VCP mutant (A232E) iPSC neurons show >60% accumulation of ubiquitinated aggregates vs WT. 2. VCP activator (ML360) reduces ubiquitinated protein aggregates by >40% in VCP mutant neurons. 3. Autophagy flux (LC3-II/ p62 turnover) normalizes to within 20% of WT after ML360 treatment. 4. Mitochondrial function (OCR) improves by >30% in ML360-treated VCP mutant neurons.",
  "challenge_type": "hypothesis_resolve",
  "scope": "single_target",
  "initial_bounty_usd": 250,
  "current_bounty_usd": 250,
  "bounty_confidence": 0.3,
  "market_price": 0.5,
  "composite_score": 0.72,
  "debate_count": 0,
  "status": "open",
  "question": "Do VCP/p97 mutations (common in IBMPFD/ALS) impair extraction of ubiquitinated autophagy substrates, causing proteasome-autophagy flux obstruction, and does VCP activation restore this flux?",
  "domain": "neurodegeneration",
  "triggered_by": "hypothesis-auto-create"
}