Version history

{
  "description": "Experiment challenge for hypothesis: Ketone Utilization Index as Metabolic Flexibility Biomarker\n\n## Mechanistic Hypothesis\n## Mechanistic Overview\nKetone Utilization Index as Metabolic Flexibility Biomarker starts from the claim that modulating HMGCS2 within the disease context of translational neuroscience can redirect a disease-relevant process. The original description reads: \"## Mechanistic Overview Ketone Utilization Index as Metabolic Flexibility Biomarker starts from the claim that modulating HMGCS2 within the disease context of translational neuroscience can redirect a disease-relevant process. The original \n\n## Target Gene/Pathway\nHMGCS2\n\n## Disease Context\ntranslational neuroscience\n\n## Evidence Supporting this Hypothesis\n[{'pmid': '34171631', 'claim': 'Brain energy metabolism derangements are detectable through metabolic imaging'}, {'pmid': '30795555', 'claim': 'Metabolic plasticity is crucial for neuronal survival'}, {'pmid': '24525128', 'claim': 'Cholesterol metabolism studies suggest broader metabolic dysfunction\n\n## Evidence Against / Caveats\n[{'pmid': 'N/A', 'claim': '13C-β-hydroxybutyrate PET imaging is not clinically available or validated'}, {'pmid': 'N/A', 'claim': 'Ketone metabolism is highly variable and influenced by diet, fasting \n\n## Composite Score\n0.819 (mechanistic plausibility: 0.70, feasibility: 0.75, impact: 0.65, confidence: 0.40)\n",
  "challenge_type": "experimental_verification",
  "scope": "single_hypothesis",
  "initial_bounty_usd": 2281,
  "current_bounty_usd": 2281,
  "bounty_confidence": 0.82,
  "landscape_score": 0.725,
  "gap_importance_score": 1.3,
  "therapeutic_potential_score": 0.583,
  "market_price": 0.5,
  "composite_score": 0.819,
  "debate_count": 0,
  "status": "open",
  "question": "Ketone Utilization Index as Metabolic Flexibility Biomarker",
  "domain": "translational neuroscience"
}