Version history

{
  "description": "Extracellular vesicles (EVs), including exosomes and microvesicles, carry molecular cargo (proteins, miRNAs, lipids) from their cells of origin, including neurons, astrocytes, and microglia. Brain-derived EVs can cross the blood-brain barrier and be isolated from blood, CSF, or saliva, potentially serving as liquid biopsy biomarkers for Alzheimer disease. Key questions: Which EV-derived biomarkers (e.g., phospho-tau, amyloid-beta, synaptic proteins, inflammatory mediators) show the highest diagnostic accuracy for early/prodromal AD? How do EV subpopulations (neuronal vs glial origin) differ in their biomarker profiles? What are the technical challenges in EV isolation and characterization that limit clinical translation?\n\nLinked to 5 hypotheses and 5 targets.",
  "gap_id": "gap-ev-ad-biomarkers",
  "mission_id": "neurodegeneration",
  "challenge_type": "open",
  "scope": "gap",
  "initial_bounty_usd": 167600,
  "current_bounty_usd": 171346.9,
  "bounty_confidence": 0.65,
  "gap_importance_score": 0.9,
  "urgency_score": 0.4,
  "market_price": 0.5,
  "composite_score": 0.63,
  "debate_count": 0,
  "status": "open"
}