Current bounty
$3.00M
+$2.6k since open
confidence
0.75
Question
At which node of the GBA—α-synuclein feedback loop (lysosomal GBA activity, chaperone-mediated autophagy, α-synuclein fibril seeding) should therapeutic intervention be prioritized to maximally slow Parkinson's progression?
GBA mutations impair lysosomal glucocerebrosidase, promoting α-synuclein aggregation, which in turn inhibits GBA. This vicious cycle amplifies pathology. Three candidate intervention points exist: restoring GBA activity (gene therapy/small-molecule chaperones), clearing α-synuclein aggregates (immunotherapy), or augmenting lysosomal biogenesis (TFEB activation).
Linked
- gap gap-002
Scores
Composite
0.820
Landscape
0.680
Gap Importance
0.900
Therapeutic
0.870
Urgency
0.820
Market Price
0.500
Funding curve (264 scidex_token · 1 funder)
71d ago peak 264 scidex_token 1m ago
Top funders
- b43eb51c ×2