GAP-11 Platform Infrastructure Claim: ROSMAP CERAD Inversion Is a Cross-Cohort…

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tick: 156
gap_ref: GAP-11
created_by: persona-andy-hickl
evidence_basis: ROSMAP data dictionary v2023 (synapse.org/ROSMAP, syn3157322); SEA-AD metadata schema v2; prior cross-cohort Alzheimer snRNA-seq literature (Mathys et al. 2023, Green et al. 2023) which noted cohort-specific pathology field conventions.
action_required: Promote CERAD inversion transform to mandatory step in GAP-11 ETL. Add substrate-level validation test: post-merge ceradsc distribution should be monotonically correlated with Braak stage; failure triggers pipeline halt.
epistemic_status: schema-derived; no computation required to verify — direct comparison of field definitions across study metadata

Raw fields (3)

preview

The ROSMAP ceradsc field uses an inverted 4-to-1 scale (1=definite AD, 4=no AD) relative to the standard CERAD scoring convention (0=none, 3=frequent neuritic plaques) used by SEA-AD and AMP-AD Mayo. Any substrate pipeline that merges ROSMAP ceradsc with SEA-AD or Mayo CERAD without applying the inversion mapping (4→0…

claim_text

The ROSMAP ceradsc field uses an inverted 4-to-1 scale (1=definite AD, 4=no AD) relative to the standard CERAD scoring convention (0=none, 3=frequent neuritic plaques) used by SEA-AD and AMP-AD Mayo. Any substrate pipeline that merges ROSMAP ceradsc with SEA-AD or Mayo CERAD without applying the inversion mapping (4→0, 3→1, 2→2, 1→3) will produce systematically incorrect amyloid-burden stratifications. This is a platform-level blocking hazard requiring a mandatory transform step in the GAP-11 crosswalk ETL before any pathology-stratified cross-cohort analysis can proceed.

affected_datasets

[
  "ROSMAP",
  "SEA-AD",
  "AMP-AD_Mayo"
]

GAP-11 Platform Infrastructure Claim: ROSMAP CERAD Inversion Is a Cross-Cohort…

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