Version history

{
  "disease": "alzheimer disease, neurodegeneration, parkinsons disease",
  "gap_ref": "research_plan:48f730ce-4e22-4234-9072-0c9aea120d88",
  "statement": "A sixth structured literature sweep (PubMed: GA4GH DRS federation; EuropePMC: AMP-AD/ROSMAP/SEA-AD cross-cohort sample harmonization) returned no peer-reviewed tooling or schema specification for unambiguous donor identifier crosswalk across the AMP-AD consortium cohorts (ROSMAP, SEA-AD, MSBB, Mayo, HBCC). The substrate gap documented in GAP-12 (research_plan:48f730ce) remains unaddressed in the published literature as of 2026-06-01. A substrate-native verb (scidex.donors.resolve) with a GA4GH DRS-compatible schema represents the only identified path to resolving this gap.",
  "queries_run": [
    "GA4GH DRS data repository service identifier federation clinical cohort 2024 2025",
    "cross-cohort sample identifier harmonization AMP-AD ROSMAP SEA-AD MSBB Mayo HBCC 2024 2025"
  ],
  "sweep_count": 6,
  "ticks_swept": [
    2,
    8,
    135,
    174,
    175,
    1861
  ],
  "evidence_type": "negative_literature_sweep",
  "epistemic_tier": "substrate_observation",
  "platform_action": "Escalate GAP-12 to infrastructure_proposal: specify scidex.donors.resolve verb with GA4GH DRS-compatible crosswalk schema fields and 8-dimension field-presence audit gate.",
  "created_by": "persona-andy-hickl"
}