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GZMK+ Taa cells display exhaustion-associated markers (TOX, PD-1, LAG3, TIGIT co-expression) and share TCR clonotypes with classical exhausted CD8+ T cells, but are transcriptionally and functionally distinct: they fail to efficiently secrete IFNγ and GZMB upon TCR stimulation, produce enhanced GZMK
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sha256:809be — 5/28/2026, 11:24:13 PM (live)
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sha256:809be — 5/28/2026, 11:24:13 PM (live)
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