Version history

{
  "scope": "mouse cortex (see paper for region/cell-type detail)",
  "claim_text": "Validation of phiC31-mediated expression and functional knockout of Opn3 in the Opn3-phiC31o knock-in mouse. Opn3-phiC31o homozygous mice showed a larger decrease in body temperature under cold exposure compared to wild-type controls.",
  "raw_fields": {
    "n": null,
    "doi": "10.1186/s40662-025-00455-z",
    "claim": "Validation of phiC31-mediated expression and functional knockout of Opn3 in the Opn3-phiC31o knock-in mouse. Opn3-phiC31o homozygous mice showed a larger decrease in body temperature under cold exposure compared to wild-type controls.",
    "cite_key": "Kwok2025",
    "evidence": "Validation of phiC31-mediated expression and functional knockout of Opn3 in the Opn3-phiC31o knock-in mouse. — Opn3 is a non-visual blue light-sensitive opsin that has recently been reported to have an expansive repertoire of biological functions. To investigate the function of Opn3-expressing cells, we aimed to generate a system in which Opn3-expressing cells can be targeted by site-specific gene recombinat",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse cortex (see paper for region/cell-type detail)",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "Opn3-phiC31o homozygous mice showed a larger decrease in body temperature under cold exposure compared to wild-type controls.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_11_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-11-pattern-completion",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-ed9ff69edf1c"
  ],
  "source_span": "Opn3-phiC31o homozygous mice showed a larger decrease in body temperature under cold exposure compared to wild-type controls.",
  "study_system": "mouse cortex (see paper for region/cell-type detail)",
  "evidence_refs": [
    {
      "ref": "paper:paper-ed9ff69edf1c"
    }
  ],
  "section_title": "11. Physiological signature III — pattern completion, replay, and sequence generation as recurrent-circuit read-outs in mouse cortex",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Validation of phiC31-mediated expression and functional knockout of Opn3 in the Opn3-phiC31o knock-in mouse. — Opn3 is a non-visual blue light-sensitive opsin that has recently been reported to have an expansive repertoire of biological functions. To investigate the function of Opn3-expressing cells, we aimed to generate a system in which Opn3-expressing cells can be targeted by site-specific gene recombinat",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-11-pattern-completion",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_11_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}