- raw_fields
{
"n": 0,
"doi": "10.1038/mp.2017.132",
"claim": "However, NRG has also been shown to modulate DA levels, suggesting a role for ErbB4 signaling in dopaminergic neuron function.",
"evidence": "Genetic variants of Neuregulin 1 (NRG1) and its neuronal tyrosine kinase receptor ErbB4 are associated with risk for schizophrenia, a neurodevelopmental disorder characterized by excitatory/inhibitory imbalance and dopamine (DA) dysfunction. To date, most ErbB4 studies have focused on GABAergic inte",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse hippocampus cortex prefrontal cortex",
"replication_status": "independently_replicated",
"claim_source_sentence": "However, NRG has also been shown to modulate DA levels, suggesting a role for ErbB4 signaling in dopaminergic neuron function.",
"replication_evidence_dois": [
"10.1016/j.ynstr.2024.100628",
"10.1016/j.neuint.2011.05.004"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-39d2f687db2e"
]
- evidence_refs
[
{
"ref": "paper:paper-39d2f687db2e"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}- evidence_summary
Genetic variants of Neuregulin 1 (NRG1) and its neuronal tyrosine kinase receptor ErbB4 are associated with risk for schizophrenia, a neurodevelopmental disorder characterized by excitatory/inhibitory imbalance and dopamine (DA) dysfunction. To date, most ErbB4 studies have focused on GABAergic inte