Transient suppression of BDNF-TrkB signaling during early development decreases…

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scope: rat medial prefrontal cortex, early postnatal development
claim_text: Transient suppression of BDNF-TrkB signaling during early development decreases PV interneuron numbers in mPFC during adolescence and impairs working memory
section_id: section_09_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_09_evidence_package.json
effect_size: Decreased PV+ interneuron numbers at PD35 resembling maternal separation phenotype
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-09
source_kind: review_finding
source_path: evidence/section_09_evidence_package.json
source_span: Repeated ANA-12 administration from PD 7 to 14 decreased the number of inhibitory neurons, particularly parvalbumin-positive interneurons, in adolescence (PD 35), which resembled the changes observed in the MS model.
study_system: rat medial prefrontal cortex, early postnatal development
section_title: Brain Region and Layer Context: Beyond Primary Sensory Cortex
evidence_summary: Transient suppression of BDNF-TrkB signaling during early development decreases PV interneuron numbers in mPFC during adolescence and impairs working memory
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-09
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_09_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1016/j.bbr.2025.115790",
  "claim": "Transient suppression of BDNF-TrkB signaling during early development decreases PV interneuron numbers in mPFC during adolescence and impairs working memory",
  "evidence": "Transient suppression of BDNF-TrkB signaling during early development decreases PV interneuron numbers in mPFC during adolescence and impairs working memory",
  "effect_size": "Decreased PV+ interneuron numbers at PD35 resembling maternal separation phenotype",
  "text_access": "fulltext",
  "study_system": "rat medial prefrontal cortex, early postnatal development",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Repeated ANA-12 administration from PD 7 to 14 decreased the number of inhibitory neurons, particularly parvalbumin-positive interneurons, in adolescence (PD 35), which resembled the changes observed in the MS model.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Repeated ANA-12 administration from PD 7 to 14 decreased the number of inhibitory neurons, particularly parvalbumin-positive interneurons, in adolescence (PD 35), which resembled the changes observed in the MS model."
}

source_refs

[
  "paper:paper-51eb9c104f22"
]

evidence_refs

[
  {
    "ref": "paper:paper-51eb9c104f22"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

Transient suppression of BDNF-TrkB signaling during early development decreases…

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