NLRP3-Mediated Piezo1 Upregulation in ACC Inhibitory Parvalbumin-Expressing Int…

NLRP3-Mediated Piezo1 Upregulation in ACC Inhibitory Parvalbumin-Expressing Interneurons Is Involved in Pain Processing after Peripheral Nerve Injury — The anterior cingulate cortex (ACC) is particularly critical for pain information processing

{
  "n": 0,
  "doi": "10.3390/ijms232113035",
  "claim": "NLRP3-Mediated Piezo1 Upregulation in ACC Inhibitory Parvalbumin-Expressing Interneurons Is Involved in Pain Processing after Peripheral Nerve Injury — The anterior cingulate cortex (ACC) is particularly critical for pain information processing",
  "title": null,
  "cite_key": "Li2022b",
  "evidence": "Reported in International journal of molecular sciences (2022); from Body of abstract.",
  "effect_size": "3",
  "text_access": "abstract_only",
  "study_system": "rat",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "replication_unknown",
  "_source_cluster_index": 324,
  "claim_source_sentence": "The anterior cingulate cortex (ACC) is particularly critical for pain information processing.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "In cellular experiments, administration of recombinant rat TNF-α (rrTNF) to the BV2 cell culture or ACC neuron primary culture elevated the protein levels of Piezo1 and NOD-like receptor (NLR) family pyrin domain containing 3 (NLRP3)."
}

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