In mouse visual cortex, two-photon calcium imaging of V1 axonal boutons arboriz…

In mouse visual cortex, two-photon calcium imaging of V1 axonal boutons arborizing in three higher visual areas (AL, PM, LM) shows that visual response preferences of presynaptic boutons in each target area match the spatial-and-temporal-frequency preferences of the recipient neurons, demonstrating that information transfer from V1 to each downstream area is functionally target-specific — produced by both higher density and higher response amplitude of functionally matched boutons.

{
  "n": 0,
  "doi": "10.1038/nn.3300",
  "claim": "In mouse visual cortex, two-photon calcium imaging of V1 axonal boutons arborizing in three higher visual areas (AL, PM, LM) shows that visual response preferences of presynaptic boutons in each target area match the spatial-and-temporal-frequency preferences of the recipient neurons, demonstrating that information transfer from V1 to each downstream area is functionally target-specific — produced by both higher density and higher response amplitude of functionally matched boutons.",
  "cite_key": "Glickfeld2013",
  "evidence": "In-vivo two-photon calcium imaging of axonal boutons of V1 neurons in higher visual areas AL, PM, LM and of post-synaptic neurons in each target area in awake mice.",
  "effect_size": "qualitative — bouton tuning matches target-area neuron tuning in mouse visual hierarchy",
  "text_access": "fulltext",
  "study_system": "mouse primary visual cortex (V1) axonal projections to higher visual areas",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "We found that visual preferences of presynaptic boutons in each area were distinct and matched the average preferences of recipient neurons. This specificity could not be explained by organization within V1 and instead was due to both a greater density and greater response amplitude of functionally matched boutons",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1101/2023.03.13.531369"
  ],
  "effect_size_source_sentence": "visual preferences of presynaptic boutons in each area were distinct and matched the average preferences of recipient neurons"
}

[
  "paper:paper-032c4af7487d"
]

We found that visual preferences of presynaptic boutons in each area were distinct and matched the average preferences of recipient neurons. This specificity could not be explained by organization within V1 and instead was due to both a greater density and greater response amplitude of functionally matched boutons

[
  {
    "ref": "paper:paper-032c4af7487d"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}