Version history

{
  "scope": "mouse; V1, visual cortex, PFC; two-photon imaging, chemogenetics; Neuron",
  "claim_text": "Reveal distinct feedback roles of ACA and ORB projections, supporting the modular organization of PFC feedback modulation.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.neuron.2025.10.037",
    "claim": "Reveal distinct feedback roles of ACA and ORB projections, supporting the modular organization of PFC feedback modulation.",
    "cite_key": "AhrlundRichter2026",
    "evidence": "The mammalian prefrontal cortex (PFC) is thought to modulate cortical sensory processing during behavior through long-range feedback projections. Subregions of the PFC, such as the anterior cingulate cortex (ACA) and ventrolateral orbitofrontal cortex (ORB), exhibit unique patterns of connectivity that may confer distinct roles in feedback modulation of sensory information. Here, we combined axonal tracing, two-photon calcium imaging, and chemogenetic manipulations in mice to determine how proje...",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "mouse; V1, visual cortex, PFC; two-photon imaging, chemogenetics; Neuron",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "These results reveal distinct feedback roles of ACA and ORB projections, supporting the modular organization of PFC feedback modulation.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "claim_rewritten_from_source": true,
    "effect_size_source_sentence": null
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-8edfacb9362d"
  ],
  "source_span": "These results reveal distinct feedback roles of ACA and ORB projections, supporting the modular organization of PFC feedback modulation.",
  "study_system": "mouse; V1, visual cortex, PFC; two-photon imaging, chemogenetics; Neuron",
  "evidence_refs": [
    {
      "ref": "paper:paper-8edfacb9362d"
    }
  ],
  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
  "source_policy": {
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "The mammalian prefrontal cortex (PFC) is thought to modulate cortical sensory processing during behavior through long-range feedback projections. Subregions of the PFC, such as the anterior cingulate cortex (ACA) and ventrolateral orbitofrontal cortex (ORB), exhibit unique patterns of connectivity that may confer distinct roles in feedback modulation of sensory information. Here, we combined axonal tracing, two-photon calcium imaging, and chemogenetic manipulations in mice to determine how proje...",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}