In mouse prelimbic PFC L2/3, opioid receptors regulate inhibitory transmission…

In mouse prelimbic PFC L2/3, opioid receptors regulate inhibitory transmission with cell-type and receptor-type specificity: DOR most strongly suppresses spontaneous IPSCs while MOR most strongly suppresses electrically-evoked GABA release; PV, SST, CCK, and VIP interneurons are differentially modulated by MOR vs DOR, and DOR acts via simultaneous pre- and postsynaptic mechanisms whereas MOR mechanisms vary across IN class.

{
  "n": null,
  "doi": "10.1523/jneurosci.1963-24.2025",
  "claim": "In mouse prelimbic PFC L2/3, opioid receptors regulate inhibitory transmission with cell-type and receptor-type specificity: DOR most strongly suppresses spontaneous IPSCs while MOR most strongly suppresses electrically-evoked GABA release; PV, SST, CCK, and VIP interneurons are differentially modulated by MOR vs DOR, and DOR acts via simultaneous pre- and postsynaptic mechanisms whereas MOR mechanisms vary across IN class.",
  "title": null,
  "cite_key": "Cole2025",
  "evidence": "Whole-cell patch-clamp + optogenetics + viral cell-type targeting in male and female mouse prelimbic PFC.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "mouse prelimbic PFC; opto + ephys, both sexes",
  "target_section": "section_05",
  "_source_cluster": "cluster_01_molecular_taxonomy",
  "replication_status": "replication_unknown",
  "_source_cluster_index": 117,
  "claim_source_sentence": "Cell type-specific optogenetics revealed that MOR and DOR differentially regulate inhibitory transmission from parvalbumin, somatostatin, cholecystokinin, and vasoactive intestinal peptide-expressing INs. Finally, we demonstrate that DOR regulates inhibitory transmission through simultaneous pre- and postsynaptic modifications to IN physiology, whereas MOR function varies between somato-dendritic or presynaptic signaling depending on cell type.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-208bbf2a3ba6"
]

Cell type-specific optogenetics revealed that MOR and DOR differentially regulate inhibitory transmission from parvalbumin, somatostatin, cholecystokinin, and vasoactive intestinal peptide-expressing INs. Finally, we demonstrate that DOR regulates inhibitory transmission through simultaneous pre- and postsynaptic modifications to IN physiology, whereas MOR function varies between somato-dendritic or presynaptic sign...

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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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