Details
- scope
- mouse hippocampal slices, optogenetics
- claim_text
- PV+ basket cells are both necessary and sufficient for ripple-frequency current and rhythm generation; tonic driving of PV+ cells evoked ripple oscillations even with excitation blocked
- section_id
- section_10_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json
- effect_size
- PV+ cell activity necessary and sufficient for ripple-frequency oscillation
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-10
- source_kind
- review_finding
- source_path
- evidence/section_10_evidence_package.json
- source_span
- Even with excitation blocked, tonic driving of parvalbumin-positive cells evoked ripple oscillations. Conversely, optogenetic silencing of parvalbumin-positive cells interrupted the SWRs or inhibited their occurrence.
- study_system
- mouse hippocampal slices, optogenetics
- section_title
- Oscillations and Network Dynamics: Gamma, Ripples, and Synchrony
- evidence_summary
- PV+ basket cells are both necessary and sufficient for ripple-frequency current and rhythm generation; tonic driving of PV+ cells evoked ripple oscillations even with excitation blocked
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-10
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1523/jneurosci.0867-14.2014", "claim": "PV+ basket cells are both necessary and sufficient for ripple-frequency current and rhythm generation; tonic driving of PV+ cells evoked ripple oscillations even with excitation blocked", "evidence": "PV+ basket cells are both necessary and sufficient for ripple-frequency current and rhythm generation; tonic driving of PV+ cells evoked ripple oscillations even with excitation blocked", "effect_size": "PV+ cell activity necessary and sufficient for ripple-frequency oscillation", "text_access": "abstract_only", "study_system": "mouse hippocampal slices, optogenetics", "replication_status": "independently_replicated", "claim_source_sentence": "Even with excitation blocked, tonic driving of parvalbumin-positive cells evoked ripple oscillations. Conversely, optogenetic silencing of parvalbumin-positive cells interrupted the SWRs or inhibited their occurrence.", "replication_evidence_dois": [ "10.1016/j.neuron.2014.06.023" ], "effect_size_source_sentence": "Local drug applications and modeling experiments confirmed that the activity of parvalbumin-positive perisomatic inhibitory neurons is both necessary and sufficient for ripple-frequency current and rhythm generation." }- source_refs
[ "paper:paper-785f6bafb4de" ]
- evidence_refs
[ { "ref": "paper:paper-785f6bafb4de" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }