Version history

{
  "scope": "europepmc_q8",
  "claim_text": "Somatodendritic Kv7/KCNQ/M channels control interspike interval in hippocampal interneurons",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.3521-06.2006",
    "claim": "Somatodendritic Kv7/KCNQ/M channels control interspike interval in hippocampal interneurons",
    "evidence": "The M-current (I(M)), comprised of Kv7 channels, is a voltage-activated K+ conductance that plays a key role in the control of cell excitability. In hippocampal principal cells, I(M) controls action p",
    "effect_size": "30 mV",
    "text_access": "abstract_only",
    "study_system": "europepmc_q8",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "In addition, 0.5 mM tetraethylammonium reduced I(M), suggesting that I(M) was composed of Kv7.2-containing channels.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Under voltage clamp (VC) conditions at -30 mV, the Kv7 channel antagonists linopirdine/XE-991 abolished the I(M) amplitude present during relaxation from -30 to -50 mV and reduced the holding current (I(hold))"
  },
  "section_id": "section_12_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_12_evidence_package.json",
  "effect_size": "30 mV",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-12",
  "source_kind": "review_finding",
  "source_path": "evidence/section_12_evidence_package.json",
  "source_refs": [
    "paper:paper-15511df91dc7"
  ],
  "source_span": "In addition, 0.5 mM tetraethylammonium reduced I(M), suggesting that I(M) was composed of Kv7.2-containing channels.",
  "study_system": "europepmc_q8",
  "evidence_refs": [
    {
      "ref": "paper:paper-15511df91dc7"
    }
  ],
  "section_title": "Computational Models of PV Circuit Function",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "The M-current (I(M)), comprised of Kv7 channels, is a voltage-activated K+ conductance that plays a key role in the control of cell excitability. In hippocampal principal cells, I(M) controls action p",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-12",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_12_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}