Details
- scope
- MPTP-treated rhesus monkeys, extracellular recording from GPe/GPi during STN HFS
- claim_text
- Therapeutic high-frequency STN stimulation in MPTP-treated monkeys increased GPe/GPi firing rates and imposed a stimulus-synchronized regular firing pattern, contradicting a simple rate-suppression interpretation of DBS.
- section_id
- section_05
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_05_evidence_package.json
- effect_size
- 136 Hz STN HFS → significant increase in mean discharge rate, stimulus-synchronized regular pattern
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-05
- source_kind
- review_finding
- source_path
- evidence/section_05_evidence_package.json
- source_span
- These short-latency responses were present with 136 Hz stimulation, at voltages effective for alleviation of parkinsonian signs, resulting in a significant increase in mean discharge rate and a stimulus-synchronized regular firing pattern.
- study_system
- MPTP-treated rhesus monkeys, extracellular recording from GPe/GPi during STN HFS
- section_title
- Pallidal Organization and the Disinhibition Principle
- evidence_summary
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- replicated
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-05
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_05_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
- raw_fields
{ "n": 110, "doi": "10.1523/jneurosci.23-05-01916.2003", "claim": "Therapeutic high-frequency STN stimulation in MPTP-treated monkeys increased GPe/GPi firing rates and imposed a stimulus-synchronized regular firing pattern, contradicting a simple rate-suppression interpretation of DBS.", "cite_key": "Hashimoto2003", "evidence": "", "effect_size": "136 Hz STN HFS → significant increase in mean discharge rate, stimulus-synchronized regular pattern", "text_access": "abstract_only", "study_system": "MPTP-treated rhesus monkeys, extracellular recording from GPe/GPi during STN HFS", "source_cluster_id": "cluster_04", "replication_status": "replicated", "claim_source_sentence": "These short-latency responses were present with 136 Hz stimulation, at voltages effective for alleviation of parkinsonian signs, resulting in a significant increase in mean discharge rate and a stimulus-synchronized regular firing pattern.", "replication_evidence_dois": [ "10.1056/nejmoa000827", "10.1146/annurev.neuro.29.051605.112824" ], "effect_size_source_sentence": "These short-latency responses were present with 136 Hz stimulation, at voltages effective for alleviation of parkinsonian signs, resulting in a significant increase in mean discharge rate and a stimulus-synchronized regular firing pattern." }- source_refs
[ "paper:paper-f353265a7640" ]
- evidence_refs
[ { "ref": "paper:paper-f353265a7640" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }