Details
- scope
- mice, channelrhodopsin-2 in D1- or D2-receptor-expressing striatal SPNs, operant task
- claim_text
- Direct-pathway D1-receptor SPN activation drove sustained reinforcement while indirect-pathway D2-receptor SPN activation produced transient punishment, supporting opposing motivational roles for the two pathways.
- section_id
- section_04
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
- effect_size
- D1 → persistent reinforcement; D2 → transient punishment
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-04
- source_kind
- review_finding
- source_path
- evidence/section_04_evidence_package.json
- source_span
- Here, we tested the hypothesis that D1-expressing direct pathway medium spiny neurons (dMSNs) mediate reinforcement, while D2-expressing indirect pathway neurons (iMSNs) mediate punishment – .
- study_system
- mice, channelrhodopsin-2 in D1- or D2-receptor-expressing striatal SPNs, operant task
- section_title
- Striatal Output Pathways: Direct, Indirect, and Beyond
- evidence_summary
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-04
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1038/nn.3100", "claim": "Direct-pathway D1-receptor SPN activation drove sustained reinforcement while indirect-pathway D2-receptor SPN activation produced transient punishment, supporting opposing motivational roles for the two pathways.", "cite_key": "Kravitz2012", "evidence": "", "effect_size": "D1 → persistent reinforcement; D2 → transient punishment", "text_access": "fulltext", "study_system": "mice, channelrhodopsin-2 in D1- or D2-receptor-expressing striatal SPNs, operant task", "source_cluster_id": "cluster_04", "replication_status": "independently_replicated", "claim_source_sentence": "Here, we tested the hypothesis that D1-expressing direct pathway medium spiny neurons (dMSNs) mediate reinforcement, while D2-expressing indirect pathway neurons (iMSNs) mediate punishment – .", "replication_evidence_dois": [ "10.1038/nature09159", "10.1038/nature17639" ], "effect_size_source_sentence": "Stimulating D1 receptor–expressing neurons induced persistent reinforcement, whereas stimulating D2 receptor–expressing neurons induced transient punishment, indicating that activation of these circuits is sufficient to modify the probability of performing future actions." }- source_refs
[ "paper:paper-64eefa703095" ]
- evidence_refs
[ { "ref": "paper:paper-64eefa703095" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }