Thalamic neurons projecting to mouse ALM exhibit selective persistent delay act…

Thalamic neurons projecting to mouse ALM exhibit selective persistent delay activity predictive of future movement direction; photoinhibition of thalamus produces near-complete collapse of ALM delay activity at short latency, and vice versa, indicating persistent activity requires reciprocal excitation across thalamus and cortex rather than purely local recurrent reverberation.

{
  "n": 0,
  "doi": "10.1038/nature22324",
  "claim": "Thalamic neurons projecting to mouse ALM exhibit selective persistent delay activity predictive of future movement direction; photoinhibition of thalamus produces near-complete collapse of ALM delay activity at short latency, and vice versa, indicating persistent activity requires reciprocal excitation across thalamus and cortex rather than purely local recurrent reverberation.",
  "cite_key": "Guo2017",
  "evidence": "Unilateral photoinhibition of delay activity in ALM or thalamus produced contralesional neglect; photoinhibition of ALM diminished thalamic activity.",
  "effect_size": "",
  "text_access": "abstract_only",
  "study_system": "mouse ALM and ventral medial thalamus; multi-region spike recordings + optogenetic inhibition during tactile delayed-response",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Here we show that, similar to ALM neurons, thalamic neurons exhibited selective persistent delay activity that predicted movement direction.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1523/JNEUROSCI.1333-18.2018",
    "10.1038/s41586-018-0633-x"
  ],
  "effect_size_source_sentence": "Photoinhibition of the thalamus caused a short-latency and near-complete collapse of ALM activity."
}

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    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
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