Microglial depletion prevents extracellular matrix changes and striatal volume…

{
  "n": 2,
  "doi": "10.1093/brain/awz363",
  "claim": "Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease",
  "evidence": "Study on PV interneuron vulnerability mechanisms",
  "effect_size": "To address the role of these cells in disease pathogenesis, we depleted microglia from R6/2 mice, a rapidly progressing model of Huntington's disease marked by behavioural impairment, mutant huntingtin (mHTT) accumulation, and early death, through colony-stimulating factor 1 receptor inhibition (CSF1Ri) with pexidartinib (PLX3397) for the duration of disease",
  "text_access": "abstract_only",
  "study_system": "PV interneuron vulnerability / oxidative stress",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Huntington's disease is associated with a reactive microglial response and consequent inflammation.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "To address the role of these cells in disease pathogenesis, we depleted microglia from R6/2 mice, a rapidly progressing model of Huntington's disease marked by behavioural impairment, mutant huntingtin (mHTT) accumulation, and early death, through colony-stimulating factor 1 receptor inhibition (CSF1Ri) with pexidartinib (PLX3397) for the duration of disease."
}

To address the role of these cells in disease pathogenesis, we depleted microglia from R6/2 mice, a rapidly progressing model of Huntington's disease marked by behavioural impairment, mutant huntingtin (mHTT) accumulation, and early death, through colony-stimulating factor 1 receptor inhibition (CSF1Ri) with pexidartinib (PLX3397) for the duration of disease

[
  "paper:paper-6844d316415f"
]

[
  {
    "ref": "paper:paper-6844d316415f"
  }
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}