Quantitative basal-ganglia network simulations require coordinated re-tuning of…

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scope: rat
claim_text: Quantitative basal-ganglia network simulations require coordinated re-tuning of GPe-STN, STN-GPe, and striatopallidal release probability to recapitulate dopamine-depleted firing patterns.
section_id: section_04
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
effect_size
review_repo: ComputationalReviewLoops
section_ref: wiki_page:computationalreviewloops-04
source_kind: review_finding
source_path: evidence/section_04_evidence_package.json
source_span: Therefore, under normal conditions, we decreased the release probability ( U ) of GPe‐STN, STN‐GPe, and Str(iSPN)‐PGPe synapses by 50% and increased that of Str(dSPN)‐AGPe by 50%.
study_system: rat
section_title: Striatal Output Pathways: Direct, Indirect, and Beyond
evidence_summary: The network configuration in Parkinsonian state compensates network activity change caused by loss of dopamine.
review_bundle_ref: analysis_bundle:ab-d49e54403ef9
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-d49e54403ef9
source_artifact_ref: wiki_page:computationalreviewloops-04
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
commit_sha: 0632aae8abc141909207fe91f6349b9e36489c3b
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.14814/phy2.15612",
  "claim": "Quantitative basal-ganglia network simulations require coordinated re-tuning of GPe-STN, STN-GPe, and striatopallidal release probability to recapitulate dopamine-depleted firing patterns.",
  "cite_key": "Kitano2023",
  "evidence": "The network configuration in Parkinsonian state compensates network activity change caused by loss of dopamine.",
  "effect_size": "",
  "text_access": "fulltext",
  "study_system": "rat",
  "source_cluster_id": "cluster_04",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Therefore, under normal conditions, we decreased the release probability ( U ) of GPe‐STN, STN‐GPe, and Str(iSPN)‐PGPe synapses by 50% and increased that of Str(dSPN)‐AGPe by 50%.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

source_refs

[
  "paper:paper-049e9f66500c"
]

evidence_refs

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  }
]

source_policy

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Quantitative basal-ganglia network simulations require coordinated re-tuning of…

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