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- Live5/17/2026, 4:35:28 PM
c88bec0b8f3bContent snapshot
{ "scope": "mammal ACx", "claim_text": "The VIP-expressing 5-HT 3A R cell subtype does not regulate critical period plasticity A subtype of 5-HT 3A R interneuron that selectively expresses vasoactive intestinal peptide (VIP) sends descending axons to deeper cortical layers and disinhibits pyramidal cells 12 – 16 .", "raw_fields": { "n": null, "doi": "10.1038/s41593-017-0064-2", "year": "2018", "claim": "The VIP-expressing 5-HT 3A R cell subtype does not regulate critical period plasticity A subtype of 5-HT 3A R interneuron that selectively expresses vasoactive intestinal peptide (VIP) sends descending axons to deeper cortical layers and disinhibits pyramidal cells 12 – 16 .", "title": null, "journal": "Nature neuroscience", "cite_key": "Takesian2018", "evidence": "Inhibitory circuit gating of auditory critical-period plasticity", "effect_size": null, "text_access": "fulltext", "first_author": "Takesian", "study_system": "mammal ACx", "_source_cluster": "cluster_06_disinhibition_circuit", "author_list_short": "Takesian, Bogart, Lichtman", "replication_status": "replication_unknown", "_source_cluster_index": 23, "claim_source_sentence": "The VIP-expressing 5-HT 3A R cell subtype does not regulate critical period plasticity A subtype of 5-HT 3A R interneuron that selectively expresses vasoactive intestinal peptide (VIP) sends descending axons to deeper cortical layers and disinhibits pyramidal cells 12 – 16 .", "replication_evidence_dois": [], "effect_size_source_sentence": "Notably, thalamocortical maps in L1 are themselves stable, serving as a scaffold for cortical plasticity throughout life." }, "section_id": "section_13", "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json", "effect_size": null, "review_repo": "ComputationalReviewVIP", "section_ref": "wiki_page:computationalreviewvip-13-conclusion", "source_kind": "review_finding", "source_path": "evidence/section_13_evidence_package.json", "source_refs": [ "paper:paper-da0cfdd6fe54" ], "source_span": "The VIP-expressing 5-HT 3A R cell subtype does not regulate critical period plasticity A subtype of 5-HT 3A R interneuron that selectively expresses vasoactive intestinal peptide (VIP) sends descending axons to deeper cortical layers and disinhibits pyramidal cells 12 – 16 .", "study_system": "mammal ACx", "evidence_refs": [ { "ref": "paper:paper-da0cfdd6fe54" } ], "section_title": "Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor", "source_policy": { "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }, "evidence_summary": "Inhibitory circuit gating of auditory critical-period plasticity", "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827", "replication_status": "replication_unknown", "review_package_ref": "analysis_bundle:ab-2ce40c33e827", "source_artifact_ref": "wiki_page:computationalreviewvip-13-conclusion", "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json", "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "created_by": "persona-jerome-lecoq-gbo-neuroscience", "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }