Neurochemical mapping of the human hippocampus reveals perisynaptic matrix arou…

{
  "n": 0,
  "doi": "10.1007/s00401-012-1042-0",
  "claim": "Neurochemical mapping of the human hippocampus reveals perisynaptic matrix around functional synapses in Alzheimer's disease",
  "evidence": "Study on PV interneurons in Alzheimer's/neurodegeneration",
  "effect_size": "We hypothesized that (1) the cellular expression sites of chondroitin sulphate proteoglycan-containing extracellular matrix associate with specific neuronal identities, reflecting network dynamics, and (2) the regional distribution and molecular composition of axonal coats must withstand Alzheimer's disease-related modifications to protect functional synapses",
  "text_access": "abstract_only",
  "study_system": "Alzheimer's disease / neurodegeneration",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Perineuronal matrix is an extracellular protein scaffold to shape neuronal responsiveness and survival.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "We hypothesized that (1) the cellular expression sites of chondroitin sulphate proteoglycan-containing extracellular matrix associate with specific neuronal identities, reflecting network dynamics, and (2) the regional distribution and molecular composition of axonal coats must withstand Alzheimer's disease-related modifications to protect functional synapses."
}

We hypothesized that (1) the cellular expression sites of chondroitin sulphate proteoglycan-containing extracellular matrix associate with specific neuronal identities, reflecting network dynamics, and (2) the regional distribution and molecular composition of axonal coats must withstand Alzheimer's disease-related modifications to protect functional synapses

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