Reconciling feature-specific suppression observed with single-neuron stimulatio…

Reconciling feature-specific suppression observed with single-neuron stimulation in mouse V1 with feature-specific E→E connectivity requires strong AND functionally specific E-I connectivity — neither inhibition dominance nor broad inhibition alone suffices.

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  "doi": "10.1073/pnas.2004568117",
  "claim": "Reconciling feature-specific suppression observed with single-neuron stimulation in mouse V1 with feature-specific E→E connectivity requires strong AND functionally specific E-I connectivity — neither inhibition dominance nor broad inhibition alone suffices.",
  "cite_key": "Sadeh2020a",
  "evidence": "Large-scale recurrent network simulations and mathematical analysis of single-neuron perturbations across connectivity regimes; calibrated to mouse V1 perturbation data.",
  "effect_size": "qualitative — strong, feature-specific E-I connectivity required; emerges population-level response gain nonlinearities",
  "text_access": "abstract_only",
  "study_system": "Mouse V1 recurrent network model (theoretical/simulation, calibrated to experiments)",
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  "claim_source_sentence": "Our numerical simulations and mathematical analysis revealed that, contrary to the prima facie assumption, neither inhibition dominance nor broad inhibition alone were sufficient to explain the experimental findings; instead, strong and functionally specific excitatory-inhibitory connectivity was necessary, consistent with recent findings in the primary visual cortex of rodents.",
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  "effect_size_source_sentence": "Such networks had a higher capacity to encode and decode natural images, and this was accompanied by the emergence of response gain nonlinearities at the population level."
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Our numerical simulations and mathematical analysis revealed that, contrary to the prima facie assumption, neither inhibition dominance nor broad inhibition alone were sufficient to explain the experimental findings; instead, strong and functionally specific excitatory-inhibitory connectivity was necessary, consistent with recent findings in the primary visual cortex of rodents.

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