- claim_text
Activity-dependent striatal synaptic plasticity at corticostriatal synapses is differentially regulated in direct- vs indirect-pathway SPNs and is altered in disease models, providing a substrate for procedural learning and a target for pathophysiology.
- raw_fields
{
"n": 0,
"doi": "10.1016/j.neuron.2008.11.005",
"claim": "Activity-dependent striatal synaptic plasticity at corticostriatal synapses is differentially regulated in direct- vs indirect-pathway SPNs and is altered in disease models, providing a substrate for procedural learning and a target for pathophysiology.",
"cite_key": "Kreitzer2008",
"evidence": "",
"effect_size": "",
"text_access": "fulltext",
"study_system": "rodent striatum review",
"source_cluster_id": "cluster_04",
"replication_status": "replicated",
"claim_source_sentence": "HFS-induced striatal LTD requires dopamine D2 receptors, G q -coupled group I mGluRs, L-type calcium channels, and CB1 receptor activation, but notably, not NMDA receptors or mAChRs ( Calabresi et al., 1992a ; Calabresi et al., 1997 ; Choi and Lovinger, 1997 ; Gerdeman et al., 2002 ; Kreitzer and Malenka, 2005 ; Sung et al., 2001 ).",
"replication_evidence_dois": [
"10.1146/annurev-neuro-061010-113641"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-71f855d96201"
]
- source_span
HFS-induced striatal LTD requires dopamine D2 receptors, G q -coupled group I mGluRs, L-type calcium channels, and CB1 receptor activation, but notably, not NMDA receptors or mAChRs ( Calabresi et al., 1992a ; Calabresi et al., 1997 ; Choi and Lovinger, 1997 ; Gerdeman et al., 2002 ; Kreitzer and Malenka, 2005 ; Sung et al., 2001 ).
- evidence_refs
[
{
"ref": "paper:paper-71f855d96201"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}